Annals of Neurology: Neuronal damage is common and evident in patients with neo-coronary severe illness

Up to 36% of new patients are reported to have neurological symptoms.
animal models and human anatomy have shown that other coronavirus (especially severe acute respiratory syndrome (SARS-CoV)) have an effect on the nervous system.
Therefore, the possibility of SARS-CoV2 (i.e. neo-coronavirus) damage to the peripheral and central nervous system (CNS) needs to be investigated to distinguish between the resulting neurological symptoms associated with structural damage or reversible neurological dysfunction, a distinction that is key to the long-term sequelae of the prognosis.
neural silk light chain (NfL) represents the main component of the neuron cell skeleton and functions in axon growth, stability, and intracellular transport; serum NfL (sNfL) is a blood type marker specifically that reflects axon damage, as shown in studies including acute central nervous system (isohythmic stroke, isohemia) and chronic (multiple sclerosis and cerebrovascular disease).
, of the University of Basel in Switzerland, measured sNfL concentrations in 29 patients with severe COVID-19, 10 with severe but non-COVID-19 patients, and 259 with healthy control.
after adjusting for neurological complications and age, they found that SNfL had higher concentrations in patients with COVID-19 than in other control groups and severe and non-COVID-19 patients.
high sNfL levels are associated with adverse short-term clinical outcomes (e.g. renal inseconcance, multiple organ failure), suggesting that nerve damage is common and more obvious in critical new crown patients.
origins: Sutter, R., Hert, L., De Marchis, G.M., Twerenbold, R., Kappos, L., Naegelin, Y., ... & Kuhle, J. (2020). Serum neurofilament light chain levels in the intensive care unit: comparison between severely ill patients with and without COVID‐19. _Annals of neurology_. Freeman Source: MedSci Original Copyright Notice: All text, images and audio and video materials on this website that indicate "Source: Mets Medicine" or "Source: MedSci Originals" are owned by Mets Medical and are not reproduced by any media, website or individual without authorization, and are authorized to be reproduced with the words "Source: Mets Medicine".
all reprinted articles on this website are for the purpose of transmitting more information and clearly indicate the source and author, and media or individuals who do not wish to be reproduced may contact us and we will delete them immediately.
at the same time reproduced content does not represent the position of this site.
leave a message here