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On June 11, Japan’s Daiichi Sankyo Co.
The past and present of the upgraded G207 G47∆
The past and present of the upgraded G207 G47∆HSV-1 G207 was developed by the team of Dr.
Dr.
In preclinical studies, G47Δ has shown anti-tumor efficacy in almost all cancer types and experimental models
Stones from other mountains are enough to attack the jade T-VEC original research team to lay a solid foundation for research and development
Stones from other mountains are enough to attack the jade T-VEC original research team to lay a solid foundation for research and developmentAs early as 2003, the British BioVex research team published an article in "Gene Therapy", proving that the deletion of ICP47 by HSV1 significantly enhanced the anti-tumor effect in BALB/c mice [3]
In 2020, the review "Clinical landscape of oncolytic virus research in 2020" published by the Journal for ImmunoTherapy of Cancer analyzed 97 independent clinical trials published on oncolytic viruses from 2000 to 2020
The first two types of oncolytic herpes simplex virus clinical data under research are stunning
The first two types of oncolytic herpes simplex virus clinical data under research are stunningThe currently approved T-VEC and G47Δ both use herpes simplex virus as a carrier, and knock out ICP34.
Replimune RP1
Robert Coffin, co-founder and CEO of American Replimune, was previously the founder of British BioVex, and T-VEC is the product of Amgen’s acquisition of BioVex
Binhui Bio-OH2
In April 2021, an article published in the Journal for ImmunoTherapy of Cancer published the clinical trial results of the safety, tolerability and anti-tumor activity of Binhui Bio-OH2 injection applied to patients with advanced solid tumors [5]
Herpes simplex virus also has the characteristics of large genome capacity, immunomodulatory molecules (such as: hGM-CSF, IL-2, IL-4, IL-10, IL-12, etc.
Reference
[1] Oncolytic herpes simplex virus vector with enhanced MHC class I presentation and tumor cell killing.
[2] Relying on the IIT data of the phase II single-arm trial, Daiichi Sankyo applied for oncolytic virus drugs to be marketed in Japan｜First site.
[3] ICP34.
[4] Replimune Poster Presentation of RP1 Update in the Skin Cancer Cohorts at the Society for Immunotherapy of Cancer (SITC) 2020Annual Meeting
[5] Intratumoral OH2, an oncolytic herpes simplex virus 2, in patients with advanced solid tumors: a multi-center, phase 1/2 clinical trial.
