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    Home > Active Ingredient News > Endocrine System > Another weight loss "artifact", the latest research progress of "swallowable intragastric balloon"!

    Another weight loss "artifact", the latest research progress of "swallowable intragastric balloon"!

    • Last Update: 2022-02-20
    • Source: Internet
    • Author: User
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    Compiled and organized by Yimaitong, please do not reprint without authorization
    .

    Introduction: An intragastric balloon that can be excreted with feces without surgery or endoscopy, brings good news for weight loss! Schematic diagram: Swallowable intragastric balloon Overweight and obesity have become an important public health problem affecting the health of Chinese residents
    .

    Obesity can be independently called obesity, and it is also an independent risk factor for cardiovascular and cerebrovascular diseases, diabetes, some cancers and other chronic non-communicable diseases that seriously affect the health of Chinese residents.
    Although the effect of bariatric surgery is excellent, it is only suitable for some people.
    , and a considerable number of people who meet the indications for surgery do not receive surgery, and other treatment methods (including diet control, exercise, drugs, etc.
    ) have poor overall results
    .

    Therefore, intragastric balloon weight loss, as a non-invasive method for weight loss, has certain potential
    .

     What is an intragastric balloon? What are the current limitations? Intragastric balloon (aIGB) is a minimally invasive obesity therapy that preserves anatomical structure.
    In short, the device is placed in the stomach by surgery or endoscope, and it plays a role in assisting weight loss by occupying the space in the stomach
    .

    Devices are typically removed after a few months in place and must be used in conjunction with a long-term guided diet and behavior modification program
    .

    However, patient tolerance and product durability limit the clinical use of the device to some extent
    .

     Advantages of Swallowable Intragastric Balloons - Swallowing Placed and Excreted in Faeces The Allurion Intragastric Balloon is different from other intragastric balloons in that it is compressed into a small capsule that is attached to a thin catheter and once swallowed It will be filled with 550ml of fluid through a catheter to create a feeling of satiety and help control hunger
    .

    The procedure is approximately 20 minutes and can be performed on an outpatient basis, thereby avoiding the burden and additional cost of surgery or endoscope placement and removal
    .

    After about 4 months, the balloon is emptied through a valve that opens automatically and then expelled with feces
    .

    Schematic: Swallowable intragastric balloon Recently, the journal Clinical Gastroenterology published the latest research progress on the efficacy and safety of the Allurion intragastric balloon.
    Dr.
    Lamai and colleagues conducted a comprehensive review of the Allurion intragastric balloon related research [in Seven studies meeting the analysis criteria were identified from 273 published studies, including 2152 participants aged 18-65 years, with mean baseline body mass index (BMI) of 32.
    1-38.
    6 kg/m²]
    .

    Studies have shown that applying the device to obese people can reduce waist circumference and triglyceride levels with fewer adverse reactions
    .

    A meta-analysis of the weight loss effect of the Allurion intragastric balloon showed a mean weight loss of 12.
    2% across studies: the pooled mean difference (MD) in BMI improvement from baseline to end of study was 0.
    88 (P=0.
    001), and in all studies The weighted mean percentage of overall weight loss during treatment was 12.
    2%
    .

     Adverse events associated with the Allurion intragastric balloon are lower than other intragastric balloons: Potential risks associated with the Allurion intragastric balloon include the possibility of early deflation, however, the rate of early balloon deflation observed in the meta-analysis was relatively lower, at just 1.
    8%
    .

    Meanwhile, other adverse reactions reported by Allurion intragastric balloon included abdominal pain (37.
    5%), vomiting (29.
    6%), diarrhea (15.
    4%) and small bowel obstruction (0.
    5%), with both abdominal pain and vomiting occurring more frequently than ORBERA™ gastric Inner Balloon System and ReShape Integrated Dual Balloon System Low
    .

    And of note, no deaths or cases of acute pancreatitis were reported in the meta-analysis of Allurion intragastric balloon studies
    .

     Summary of this article Studies have shown that the Allurion intragastric balloon, which can be swallowed, does not require surgery or endoscopic placement, has demonstrated high efficiency in weight loss and improved metabolism with fewer adverse events than other existing intragastric balloons
    .

     Reference: [1]Nancy A.
    Melville.
    Swallowable Intragastric Balloon Shows Significant Weight Loss[EB/OL].
    [2022-1-12].
    https:// 2] Ramai D, Singh J, Mohan BP, et al.
    Influence of the Elipse Intragastric Balloon on Obesity and Metabolic Profile: A Systematic Review and Meta-Analysis[J].
    J Clin Gastroenterol, 2021,55(10):836- 841.
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