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Scientists have found a protein (TIMP2) in human cord blood that can inerate the sea mass of elderly mice and enhance their cognitive function, according to a major study related to aging published online in the British journal Nature.
the discovery of the protein could help develop treatments that target brain aging, making it an important step in anti-aging research.
past studies have shown that young blood components can re-create aging tissue, which can have harmful effects on young tissue.
scientists have determined that a protein that appears to be present in plasma plays a key role, and that levels of the protein decline with age, whether in laboratory mice or humans.
Team Tony Weiss-Kerry, a researcher at Stanford University School of Medicine in the United States, has been conducting clinical studies of young blood against aging.
they have shown that blood-sourced factors in younger mice can resist changes in older mice as they age.
, the researchers claim in a paper that human umbilical cord blood has a similar effect.
also identified the protein that promotes anti-aging effects, the tissue metal protease inhibitor-2 (TIMP2).
this is a protein THATP2 that occurs naturally in the early stages of development, and the protein TIMP2 appears in the brains of older mice after being injected with human umbilical cord blood.
experiments showed that after treatment, the brains of older mice expressed more genes that promote synapse formation, and that the body was an important center for learning memory, and that experimental animals showed significant improvements in tests such as learning, memory, and synth plasticity (the brain's ability to change and adapt to new information).
taken together, the new findings mean that systemic factors in the early stages of life help to resize older tissue, and TIMPS2 or its targeted cells are likely to be the target for future development of drugs to combat human aging, the researchers said.
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