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Anti-gout drug benzbromarone, must pay attention to these 8 precautions!

 Last Update: 2023-02-01
 Source: Internet
 Author: User

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Gout is a common chronic inflammatory joint disease, the incidence is increasing year by year, the severity of arthritis itself and its diverse complications make it a major problem
that plagues human health.

As an anti-gout drug, benzbromarone can be used to treat primary hyperuricemia, gouty nodularity and gout caused by various causes, and pay attention to these 8 precautions in clinical safety medication, follow the "clinical decision-making assistant - evidence-based medicine" to see!
★ (1) It cannot be taken during the acute attack of gout, because at the beginning of the treatment stage, with the dissolution of uric acid in the tissue, it may aggravate the disease;
★ (2) Usually take benzbromarone according to the prescribed dose and method, gout will not occur in the early stage of treatment, but if the attack occurs, it is recommended to halve the amount of medicine used, and colchicine or anti-inflammatory analgesics can also be used as needed to relieve pain;
★ (3) Drink a lot of water during treatment to increase urine output (the initial water intake should not be less than 1.
5-2L).

Regularly measure the pH of urine, in order to promote urine alkalinization, sodium bicarbonate or citric acid mixture can be given as appropriate, and pay attention to acid-base balance
.
The patient's urine pH should be adjusted between
6.
2-6.
8.

★ (4) When using drugs for a long time, liver function should be checked regularly [1-5].

★ (5) In the process of medication, close attention should be paid to loss of appetite, nausea, vomiting, general fatigue, abdominal pain, diarrhea, fever, thick urine, conjunctival yellowing of the eyeball and other phenomena, once it occurs, the drug should be stopped immediately and informed to the doctor [1-2][5].

★ (6) A large amount of uric acid is excreted with urine at the beginning of treatment, so the dose at this time should be small (starting dose).

★ (7) For patients with hyperuricemia caused by hematopoietic system diseases (that is, secondary hyperuricemia caused by blood diseases), this product
can only be taken after consulting a doctor.

★ (8) Simultaneous use with other hepatic damage drugs should be avoided [1-2].

What are the commonly used first-line drugs for lowering uric acid? What are the drugs used to treat acute attacks of gout?
Where to see more common rheumatology medicines? Open "Clinical Decision Assistant - Evidence-based Medicine"
to search for related disease names/drug names, one click directly! 👇

Download the Decision Assistant App and check it anytime, anywhere~

References: [1] Drug information: benzbromarone tablets, Yichang Dongguang Changjiang Pharmaceutical Co.
, Ltd.
, Sinopharm H20040348 [2] Drug information: benzbromarone tablets, German Hermann Pharmaceutical Factory (Excella GmbH & Co.
KG), imported drug registration certificate number H20171301, H20171302 [3] Drug information: benzbromarone tablets, Changzhou CommScope Pharmaceutical Co.
, Ltd.
, Sinopharm H19990335; 2012/10/01.
[4]Drug information: benzbromarone capsules, Kunshan Longdeng Reddy Pharmaceutical Co.
, Ltd.
, Sinopharm H20010790; 2012/10/01.
[5]Drug information: benzbromarone capsules, Chengdu Huashen Group Co.
, Ltd.
Pharmaceutical Factory, Sinopharm H20040592; 2007/3/22.
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