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    Home > Active Ingredient News > Digestive System Information > Anti-phantom star solution to pylori - a new way to treat Helicobacter pylori!

    Anti-phantom star solution to pylori - a new way to treat Helicobacter pylori!

    • Last Update: 2023-01-05
    • Source: Internet
    • Author: User
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    Introduction: Xie You'an can target and sweep away harmful Helicobacter pylori, while enhancing human immunity, reducing the side effects caused by antibiotic treatment, neutralizing the cytotoxicity of Helicobacter pylori, no side effects, no drug resistance, no antibiotics, no allergens
    .

    Helicobacter pylori (Hp) may still be a relatively unfamiliar word for the public, but when it comes to gastritis and gastric ulcers, the public may be more familiar with them, because these diseases are high, and family and friends around them may suffer from such diseases
    .

    In fact, Helicobacter pylori infection is closely related
    to these diseases.
    Helicobacter pylori infection is the initiator of the disease process from superficial gastritis, to gastric ulcer, to atrophic gastritis
    , and finally to gastric cancer.
    Therefore, the World Health Organization lists Helicobacter pylori as a class I carcinogen
    .

    At present, Helicobacter pylori infection is treated in hospitals, generally using quadruple therapy, and the time of taking the drug is 14 days
    .
    However, due to taking too many drugs, the amount of medication is relatively large, and the time of taking it is also very long
    .
    It can cause many side effects, such as abdominal pain and antibiotic-related diarrhea
    .
    Therefore, many patients cannot adhere to the 14-day standard to complete the treatment process
    .
    This irregular treatment will cause incomplete killing of Helicobacter pylori, resulting in the resurgence
    of Helicobacter pylori.
    When eradication occurs again, it is likely that Helicobacter pylori resistance will increase and be more difficult to eradicate
    due to the last antibiotic administration.

    In addition, it is aimed at children, the elderly, antibiotic allergy, liver and kidney dysfunction in some patients
    .
    Taking large doses of drugs for a long time can do more harm than good
    .
    Therefore, for this part of the population, doctors will carefully evaluate the medication
    .

    Because of the various drawbacks of Helicobacter pylori antibiotic therapy, whether there are new ways to control Helicobacter pylori infection has also become a hot spot
    in academic research.
    In the exploration of these new approaches, probiotics and immunoglobulins are among the very important and effective methods
    .

    (Solved pylori can effectively eradicate Helicobacter pylori)

    01 Lactobacillus reuteri DSM17648

    In the study of probiotic control of Helicobacter pylori, Lactobacillus reuteri DSM17648 can be described as a heterogeneous "bacteria" protrusion
    .

    Nuts: A new approach to Helicobacter pylori control

    In 2013, the world's top journal Nutrients published an article proposing that Lactobacillus reuteri DSM17648 could be used as a new way
    to control human Helicobacter pylori infection.
    Next, I will introduce you to the general content
    of this study.

    The trial screened 364 participants, of whom 22 tested positive for Helicobacter pylori, and values showed a moderately high
    rate of Helicobacter pylori colonization.
    Participants did not drop out
    throughout the trial phase.
    There were large between-to-individual variation in quantitative measurements of colonization at baseline and during treatment, as well as large variation in individual measurements
    .
    The primary analysis of the reduction in Helicobacter pylori by DSMZ17648 was based on the median of the absolute value of the 13C expiratory value at baseline, after placebo treatment, and after active treatment
    .

    The results were shown to include absolute values in the pilot phase and absolute and relative differences
    between baseline and supplementation phases.
    Only a statistically significant difference between 13C UBT at baseline (median=20) and after supplementation with DSMZ17648 (median=16) was statistically significant (p=0.
    011), while there was no difference between baseline and placebo (median=18) (p=0.
    237).

    The DSMZ17648 group had a statistical trend lower than placebo (p=0.
    084).

    The trial calculated both absolute differences in individuals and change scores (percentage change from baseline).

    For DSMZ17648, both the absolute difference and the change score were significant (p=0.
    018 and 0.
    013, respectively), indicating a decrease in Helicobacter pylori (see figure below).

    For placebo, there was no significant difference from 0 for either absolute or relative change, indicating a random change rather than a systemic reduction
    .

    The 13C expiratory values were repeated 6, 12, and 24 weeks after the end of supplementation to test long-term effects
    .
    The results are shown in the chart below, and a significant decline
    immediately after supplementation can still be detected after 24 weeks.

    In terms of safety: no side effects were reported
    within 14 days of placebo or DSMZ17648 supplementation.
    Before and after the supplementation period, there were no statistically significant changes
    in intact blood cell profiles or circulating metabolic enzymes measured by liver and kidney function as safety parameters.
    No changes in lifestyle (physical activity, diet) or general health as shown in the questionnaire were found during the study
    .

    The final conclusion was that Lactobacillus reuteri DSMZ17648 has many potential applications
    .
    It can reduce the burden of Helicobacter pylori in people with a high prevalence or be used as a short-term prophylaxis
    during periods of high stress.
    Lactobacillus reuteri DSM17648 can also be used for long-term prophylaxis
    .

    Probiotics Antimicro: Significantly reduces Helicobacter pylori

    In 2015, the world's top journal Probiotics Antimicro published an article proposing that Lactobacillus reuteri DSM17648 can significantly reduce the level
    of Helicobacter pylori infected in humans.
    Next, I will introduce you to the general content
    of this study.

    Experimental background:

    Helicobacter pylori is a recognized pathogen and carcinogen
    that causes gastritis, ulcers, and stomach cancer.
    More than 50% of the world's population is infected with this bacteria
    .
    The severity of the clinical manifestations of infection is related to
    the number of bacteria.

    Currently, the only treatment options are triple therapy or quadruple therapy
    .
    Eradication therapy has serious side effects and even antibiotic resistance
    .

    Purpose of the experiment:

    DSM17648 Lactobacillus reuteri (inactivated) may be shown to be effective in the treatment of Helicobacter pylori in addition to antibiotics, reducing the number of Helicobacter pylori in the stomach through interactions, and is an effective and innovative method
    against gastric pathogens.

    Experiment 1: Consists of two sets of experiments (a) and (b):

    (a) Fluorescence microscope with magnification × 1000
    .

    A.
    Probiotics colored with fluorescein carboxydiacetate, marked green
    .

    B.
    Aggregates showing agglutination of both strains under a fluorescence microscope
    .

    C.
    Helicobacter pylori colored with ethidium iodide, marked in red
    .

    (b) Microscopic analysis
    of Reuterian DSM17648 with Helicobacter pylori polymer.

    A.
    Clear liquid
    of Helicobacter pylori.

    C.
    Lactobacillus reuteri DSM17648 transparent liquid
    .

    B.
    Macroscopic polymer
    formed by Helicobacter pylori and Lactobacillus reuteri DSM17648.

    The results showed that a single cell of Lactobacillus reuteri DSM17648 bound to several Helicobacter pylori cells, resulting in cross-linking of co-aggregates and playing a polymeric role
    .

    The picture above is the picture taken by the scanning electron microscope, and the image on the left is the image after ×1800 magnification; On the right is an image
    of ×11,000 magnification.
    Polymers
    formed by Lactobacillus reuteri DSM17648 (blue) and Helicobacter pylori (red) can be observed.

    Experiment 2: Simulate the stomach environment to observe the reaction of the two

    Between gastric acid pH 2 and PH 8, the resulting polymers
    can also be observed by adding pepsin and Helicobacter pylori, and adding Lactobacillus reuteri DSM17648 culture medium.

    The results showed that Lactobacillus reuteri DSM17648 was only effective against Helicobacter pylori type I and II, and had no effect
    on commensal bacteria such as Streptococcus salivarius, Clostridium clostridia, Bacteroides fragiligis and Escherichia coli.

    Experiment 3: Experimental evaluation of patients with Helicobacter pylori

    Subjects: 128 subjects, 47 twins and 34 singles; Twenty-seven of the participants had positive breath tests
    .
    The overall prevalence of Helicobacter pylori was 21%; Six twins were consistent, while 10 twins were positive, and 14 treatments
    were initiated.
    Throughout the study, no changes were made to participants' lifestyle, exercise habits, or eating habits
    .

    It was divided into 2 groups, placebo group and DSM17648 Lactobacillus reuteri treatment group, and the experimental duration was 2 weeks
    .

    The results showed that the left figure was the treatment group and the right figure was the placebo group
    .
    After 2 weeks, the data of H.
    pylori in the DSM17648 Lactobacillus reuteri treatment group were significantly reduced
    .

    The above experiments prove the view of this article: Lactobacillus reuteri DSM17648 can polymerize with Helicobacter pylori, and only works against Helicobacter pylori, will not have any effect on other flora, and clinical experiments have proved that the clearance of Helicobacter pylori is effective
    .

    02 Egg yolk immunoglobulin IgY

    Egg yolk immunoglobulin (IgY) is a specific antibody formed in the blood of birds when stimulated by an antigen, and these antibodies are transferred and stored in
    the yolk.
    Specific IgY directly binds to the target of pathogenic bacteria, changes its overall structure, thereby achieving inhibition, in addition, under the action of digestive enzymes, part of IgY is decomposed into small peptides, which are absorbed by the body into the blood, and can be combined with pathogen adhesins in the blood, so that it loses its pathogenicity
    .

    Advantages of IgY:

    1.
    Strong thermal stability: at room temperature, the activity of IgY can be maintained for 6 months, under the condition of 4 °C, the activity of IgY can be maintained for more than 20 years, when the temperature reaches 70 °C, the activity of IgY can still be maintained for 90min, and the activity will completely disappear
    after boiling for more than 10min.

    2.
    Acid and alkali resistance: When the pH is in the range of 4-11, IgY can still maintain activity, and in combination with 40% sucrose aluminum, the activity
    of IgY can be completely maintained in the environment of pH=2.

    3.
    Anti-enzymatic hydrolysis: in the environment of pH=2, pepsin and IgY are incubated for 1h, IgY is completely inactive, but after incubation for 1h under the condition of pH=4, the activity can maintain more than 91%, and even 63% activity after 10h
    .
    It was incubated with trypsin and chymotrypsin for 8 h, still maintaining 39% and 41% activity
    .

    4.
    Does not bind to risk factors, has no complement active system, and does not cross-react
    with mammals on serum.

    5.
    Egg-derived IgY can be used directly as a natural food ingredient, safe and non-toxic, and will not produce drug resistance
    .

    Due to these characteristics of IgY, after decades of research, IgY has been widely used in food, disease prevention, immunodetection and other fields
    .
    A large number of experiments have been studied to study the effectiveness of IgY in the treatment of
    Hp infection.
    Generally, specific IgY antibodies are prepared by using viruses, Hp whole bacteria or specific pathogenic factors as immunogens, and the prepared IgY antibodies can achieve the purpose
    of inhibiting the growth and reproduction of Hp and its pathogenic factors, eradicating Helicobacter pylori, curing infection and reducing recurrence rate.

    Study of the effect of IgY antibodies on Helicobacter pylori in vitro and in vivo

    Studies have found that the toxic protein "vacuolatin" on the Hp disease strain plays an important role
    in this.
    Effective treatment
    is obtained by neutralizing toxic proteins with oral IgY antibody preparations.

    This experiment aims to study the neutralizing effect of IgY antibodies on Hp cytotoxicity and the therapeutic effect
    on infected Mice with Hp.

    Take Hp-infected BALB/c mice and divide them into three groups of 11 mice
    each.
    The first two groups took IgY1 and IgY2 10 mg orally 1 day apart for a total of three times
    .
    The remaining group did not take IgY, and 3% NaHCO3 0.
    2ml was taken before feeding, and set as the control group
    .
    After 2, 4, 6 and 8 weeks, the mice were sacrificed in batches, and the gastric mucosa was extracted, and bacterial culture, urease test and pathological examination
    were done.
    The results are as follows:

    Table 5 shows that the Hp negative conversion rate of IgY1 mice after 2, 4, 6 and 8 weeks reaches 66.
    7%, 100%, 100% and 100%, and the Hp negative conversion rate of IgY2 mice after 2, 4, 6 and 8 weeks reaches 100%, 66.
    7%, 100% and 100%, suggesting that after two weeks of oral antibody IgY, the antibody can neutralize Hp protein toxins in vivo and eradicate or reduce Hp infection
    .

    The gastric pathological sections in Figures 2 and 3 show that gastric inflammation caused by Hp can be significantly reduced or even disappeared
    after oral administration of IgY antibodies.

    Experimental conclusions

    IgY antibodies can neutralize Hp toxin cytotoxicity and reduce or eradicate Hp damage
    to cells.
    In addition, after 2 weeks of oral IgY antibody, the negative conversion rate of Hp was significantly increased, and the negative conversion rate could reach 100% after 4 weeks, and more pathological sections showed that gastric cell inflammation was significantly reduced or disappeared
    after oral IgY antibody.
    In summary, people can neutralize the toxic protein of Helicobacter pylori by oral IgY antibody preparations to achieve the purpose of
    eradicating Hp infection.

    summary

    1.
    Experiments have proved that Lactobacillus reuteri DSM17648 can polymerize with Helicobacter pylori, and only work against Helicobacter pylori, will not have any effect on other flora, and clinical experiments have proved that the clearance of Helicobacter pylori is effective
    .

    2.
    IgY has a good bacteriostatic effect on Hp in vitro and in vivo, can significantly inhibit the growth and reproduction of bacteria and the activity of pathogenic factors in vitro, and can eradicate Hp in animals, protect gastric epithelial cells and gastric mucosa to cure Hp infection
    .

    Whether it is Lactobacillus reuteri DSM17648 or egg yolk immunoglobulin IgY, it is a new treatment method for Helicobacter pylori, which has been verified by sufficient basic experiments and clinical experience, compared with the traditional antibiotic-based treatment regimen, these two ingredients have few side effects and are not easy to develop drug resistance, which is expected to become a new generation of clinical treatment options
    .

    If the two are used in combination, the therapeutic effect on Helicobacter pylori will be more significant!

    Lactobacillus reuteri DSM17648 and egg yolk immunoglobulin are specially added, Lactobacillus reuteri DSM17648 as a patented bacterium can specifically identify and anchor the bacterial membrane receptor of Helicobacter pylori, and physically bind and entangle to form an insoluble polymer, so that Helicobacter pylori can not be fixed on the pyloric wall and excreted
    。 Egg yolk immunoglobulin IgY can bind to the target of Helicobacter pylori to make it lose its pathogenicity, and can neutralize the cytotoxicity of H.
    pylori toxin, reduce or damage to cells, and enhance the inhibitory effect
    of the gastrointestinal tract on Helicobacter pylori.

    It can be used to deal with Helicobacter pylori infection and improve the effect of treating Helicobacter pylori, especially for the following people:

    1.
    People with Helicobacter pylori infection who have failed antibiotic treatment

    2.
    Multiple treatment of antibiotic-resistant Helicobacter pylori infected people

    3.
    People infected with Helicobacter pylori who are insensitive to antibiotics

    4.
    People with Helicobacter pylori infection who do not want antibiotic treatment and are worried about side effects

    5.
    Young and elderly groups that are not suitable for treatment with antibiotics

    Xieyou'an has the advantages of sweeping, bacteriostasis, anti-inflammation and prevention, which can target and sweep harmful Helicobacter pylori, enhance human immunity, reduce the side effects caused by antibiotic treatment, neutralize the cytotoxicity of Helicobacter pylori, no side effects, no drug resistance, no antibiotics, no allergens, promote the health of the intestinal digestive system, and can accurately, efficiently and safely solve Helicobacter pylori and the stomach symptoms
    it brings.

    In order to help more patients affected by Helicobacter pylori get rid of their pain, we specially launched the blockbuster product of Xieyouan, six boxes a cycle, 1~2 bottles per day, gradually relieve stomach-related symptoms, and restore your gastrointestinal health
    .

    Tips

    If there are abdominal pain, bloating, acid reflux, heartburn and other symptoms of epigastric discomfort, and chronic gastritis, gastric mucosal intestinal metaplasia, gastric polyps, residual stomach, gastric giant fold sign, chronic gastric ulcer and gastric epithelial dysplasia and other lesions, as well as objects with a family history of tumors, it is necessary to pay attention to whether they have Helicobacter
    pylori.
    If you need to know about Helicobacter pylori, you can leave a message in the background to consult our professional staff
    .

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