Antibiotic-Dietary Supplement Combination Improves Cognitive Ability in Mouse Model of Dementia

Research by scientists from the Graduate School of Medicine at Osaka City University has shown that combining the generic antibiotic rifampicin with the dietary supplement resveratrol, intranasal administration may prevent neurodegenerative diseases (such as Alzheimer's disease) A feasible method

Research leader Dr.

Neurodegenerative dementias include Alzheimer's disease (AD), frontotemporal dementia (FTD) and dementia with Lewy bodies (DLB)

Despite the "active efforts" made by researchers and pharmaceutical companies, there is no effective treatment for neurodegenerative dementia

The newly reported study builds on the team’s previous experiments on mice.

However, oral rifampicin is associated with side effects such as liver damage and drug-drug interactions

The team also wants to identify potential compounds that may help ensure the long-term safety of rifampicin for nasal use

Resveratrol is a natural antioxidant in plants and is widely used as a dietary supplement

In their latest report, the research team used a fixed dose of rifampicin and resveratrol intranasally injected 5 days a week for 4 weeks to give patients with Alzheimer’s disease, frontotemporal dementia and Lewy small A mouse model of physical dementia