Antibiotic use after birth has important effects on infant gut microbiota and resistance

The importance of the human gut microbiota to health and disease is important

Recently, a research paper titled "Effects of early-life antibiotics on the developing infant gut microbiome and resistome: a randomized trial" published on Nat Commun focused on neonates who received antibiotics within one week of birth.

In the present study, 147 infants born at ≥36 weeks requiring broad-spectrum antibiotics for sEONS in the first week of life were randomized to receive three commonly used intravenous antibiotic combinations, namely penicillin + gentamicin, Co-clavulanate + gentamicin or amoxicillin + cefotaxime (ZEBRA study, trial registration NL4882)), the mean duration of antibiotic treatment was 48 hours

The results showed that the entire gut microbial community composition and antimicrobial resistance genes were shifted after direct treatment (R2 = 9.

Average relative abundance of gut microbes in infants

These data suggest that empirical use of antibiotics can cause adverse gut microbiological side effects (Bioon.

references:

Reyman, M.