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Antibody | Looking at the research and development overview of the popular target Claudin 18.2 from the FDA approval of TJ-CD4B in Phase 1 clinical trials

 Last Update: 2021-04-19
 Source: Internet
 Author: User

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TJ-CD4B is an innovative bispecific antibody that simultaneously targets the tumor antigen claudin 18 splicing body 2 (Claudin 18.

Preclinical studies have shown that even in the case of low expression of Claudin 18.

This time, approved in the United States is a multi-center Phase 1 dose-climbing trial, which will evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of TJ-CD4B in patients with advanced or metastatic solid tumors.

Claudins are a family of proteins whose role is to maintain tight junctions that control the exchange of molecules between cells.

Claudin 18.

Current status of Claudin 18.

It is the highly selective expression of Claudin 18.

SPX-301 is a bispecific antibody drug developed by Sparx that simultaneously targets claudin18.

CLDN 18.

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