Anticancer Res: Effects of different doses of oral vitamin D3 supplements on healthy adult gut microbiome.

The purpose of this study is to explore the effects of vitamin D3 supplementation on the gut microbiome.
included 20 adults with vitamin D deficiency/deficiency, and given 600, 4000 or 10000 IUs/day oral vitamin D3.
collect stool samples at baselineand 8 weeks, using 16S rRNA gene amplification and sequencing to determine the gut microbiome.
results showed that the baseline serum 25 (OH)D was associated with an increase in the relative abundance of Akhmancia and a decrease in the relative abundance of rickets (P.lt;0.05).
intervention, we observed an increase in dose-dependent dose-dependent relative abundance of the Genus, with significant differences between 600 IUs and 10000 IUs groups (p-0.027), and significant differences between the 600 IUs and 4000 IUs groups (p-0.039).
in general, the results show that the increase in serum 25 (OH)D is associated with an increase in beneficial bacteria and a decrease in pathogenic bacteria. After vitamin D3 supplementation
, dose-dependent increases were observed in bacteria associated with reduced inflammatory bowel disease activity.
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