Anticholinergic drugs or Alzheimer's disease

Although we don't know the real cause of Alzheimer's disease, we know that some things may be the cause of Alzheimer's disease, such as heredity, age, smoking and drinking behavior, or high cholesterol level consistent with the risk of heart disease and plaque accumulation in blood vessels< br / > surprisingly, a recent paper published in JAMA Internal Medicine reported another possible factor: anticholinergic drugs may significantly increase the risk of Alzheimer's disease< br / > on 06 / 27 / 2019 < br / > its specific drug types include prescription drugs for the treatment of depression, lung disease and Parkinson's disease, as well as over-the-counter drugs for allergiesIt is worrying that these drugs are popular among the middle-aged and elderly population< br / > re demonstration of acetylcholine hypothesis < br / > this study was carried out by Carol Coupland, Professor of primary health care medical statistics at the University of Nottingham, UK, and his research teamThey selected about 285000 volunteers aged 55 and over from more than 1500 medical record databases in the UK, and followed up for 20 years< br / > they unexpectedly found that nearly 58000 of them were diagnosed with Alzheimer's disease, and those who took the most anticholinergic drugs were about 50% more likely to have Alzheimer's than those who never took them< br / > on 06 / 27 / 2019 < br / > at this point, you will doubted why anticholinergic drugs are associated with Alzheimer's disease? < br / > looking back at the current hypothesis of Alzheimer's disease, we can see that the acetylcholine hypothesis is the first hypothesis of pathogenicity< br / > as an important neurotransmitter involved in many nervous system functions, acetylcholine plays an important role in regulating muscle and controlling information transmission to the nervous systemIf the nervous system reduces the production of acetylcholine, a neurotransmitter, it will increase the risk of Alzheimer's disease< br / > although many previous studies have confirmed that long-term administration of anticholinergic drugs may have side effects of memory loss or confusionIn this study, the researchers further found the action component of blocking acetylcholine in anticholinergic drugsAt the same time, the results of the study just made a large-scale observational test for the hypothesis of acetylcholine< br / > in order to further demonstrate the acetylcholine hypothesis, the researchers looked at the medical records of patients diagnosed with Alzheimer's disease in this study, and examined the prescription drugs they took 10 years before their diagnosis, and compared the situation with those who did not< br / > after comparison, the risk of Alzheimer's disease was increased by about 50% in those who took strong anticholinergic drugs every day for about 3 years during the follow-up periodAt the same time, anticholinergic drugs were found to be more closely related to patients diagnosed with Alzheimer's disease before the age of 80< br / > do all anticholinergic drugs have this side effect? < br / > 56 anticholinergic drugs were studied in this study But not every drug is associated with an increased risk of Alzheimer's Only a few antidepressants, epilepsy drugs and drugs used to control the bladder are associated with an increased risk of Alzheimer's disease < br / > on 06 / 27 / 2019 < br / > related drugs: < br / > antidepressants: amitriptyline, paroxetine, demetrine and doxepin < br / > antiepileptics: carbamazepine and oxcarbazepine < br / > antipsychotics: quetiapine, olanzapine, chlorpromazine and perphenazine < br / > drugs for Parkinson's disease: benazine, oxfenalin and benhexol < br / > drugs for bladder control: darinacin, Fexolodine, There is no correlation between oxibunin and tolterodine < br / > drugs: < br / > antihistamines: diphenhydramine and hydroxylazine < br / > antispasmodics for gastrointestinal animals: bicyclamine and hyscineproppanthyline < br / > isoprenaline bronchodilators: isoprotobromium < br / > antiarrhythmic drugs: propylamine < br / > skeletal muscle relaxants: tizanidine and methocarbamol < br / > more complete explanations are needed in the future < br / > although such research results are interesting, many scientists do not think that drug treatment is a clear risk factor for the disease < br / > first, the study was designed to examine the link between drugs and Alzheimer's rather than causality < br / > Second, as Keith Fargo, director of science programs and outreach at the Alzheimer's Association, commented, "this is a very large study and seems to be well designed, but the problem with this kind of study is that no matter how you design it, it is impossible to completely control all possible confounding variables < br / > what can't be completely ignored is that when patients take this kind of drugs, to a large extent, there has been a high potential risk associated with Alzheimer's disease, rather than the cause of the drugs < br / > Keith Fargo is also not optimistic about whether this research result can change the current clinical code He said the results are unlikely to change the way doctors prescribe drugs, at least more research is needed to clarify how such drugs affect the risk of Alzheimer's disease < br / > reference materials: < br / > [1] aspire the headlines, we don't yet know if antichlenergic drugs contribute to dementia risk < br / > [2] risk for dementia may increase with long term use of certain medicine