Antioxidants: Is coffee a panacea for metabolic disorders in patients with chronic hepatitis B virus infection?

Hepatitis B virus (HBV) infection affects host metabolic pathways
.

It is associated with lower serum total cholesterol, high-density lipoprotein (HDL) cholesterol, and triglyceride (TG) levels

It is associated with lower serum total cholesterol, high-density lipoprotein (HDL) cholesterol, and triglyceride (TG) levels

These five methionine components appear to play different roles in the pathogenesis of liver disease in HBV-infected individuals
.

For example, hepatitis B patients with advanced chronic liver disease had significantly lower total cholesterol than patients without chronic liver disease

People with chronic hepatitis B virus (HBV) infection have a high risk of liver disease progression, which is positively associated with metabolic disturbances and negatively associated with dyslipidemia
.

Diet, including dietary antioxidants, is a lever for the management of metabolic disorders

OBJECTIVE: Our goal was to test whether this association occurs in people with hepatitis B virus infection
.

Based on cross-sectional data from the ANRS CO22 Hepather cohort, we used (I) dyslipidemia, (Ii) hypertension, and (Iii) diabetes as outcomes, and demographic, clinical, and social behavioral (including coffee consumption) data as explanatory variables, Run a logistic regression model

Results: Among 4,746 HBV-infected patients, drinking 3 cups of coffee per day was associated with an increased risk of dyslipidemia (adjusted odds ratio [95% confidence interval] 1.
49 [1.
10-2.
00], p=0.
009) and increased risk of dyslipidemia Risk reduction in blood pressure (0.
64 [0.
50-0.
82], p=0.
001); ≥ associated with risk of dyslipidemia (adjusted odds ratio [95% confidence interval] 1.
49 [1.
10-2.
00], p=0.
001)
.

Figure 1.
Frequency of metabolic disorders in the study population (ANRS CO22 Hepather cohort)

Figure 1.
Frequency of metabolic disorders in the study population (ANRS CO22 Hepather cohort)

Table 1.
Factors associated with dyslipidemia (ANRS CO22 Hepather cohort, n=4746)

Table 1.
Factors associated with dyslipidemia (ANRS CO22 Hepather cohort, n=4746)

Table 2.
Diabetes-related factors (ANRS CO22 Hepather cohort, n=4746)
.

Table 2.
Diabetes-related factors (ANRS CO22 Hepather cohort, n=4746)
.

Conclusion: It has nothing to do with diabetes
.

In HBV-infected patients, increased coffee consumption was associated with an increased risk of dyslipidemia and a reduced risk of hypertension, both effects predicted to be associated with favorable clinical outcomes

It has nothing to do with diabetes

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