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Picture: Radiation therapy (middle) destroys the structure
of the mouse small intestine compared to the control group (left).
Image source: ?2022 was originally published in the Journal of Experimental Medicine
.
Researchers have found that inhibiting a protein called GABA by a receptor protects intestinal stem cells from the toxic effects
of chemotherapy and radiotherapy.
Because they must constantly proliferate and replace cells in the intestinal wall, intestinal stem cells are highly sensitive
to chemotherapy and radiotherapy.
A team led by Dawei Chen and Jingxin Li of Shandong University College found that levels of a protein called GABRA1 increased
in the intestinal stem cells of mice treated with radiotherapy or chemotherapy drugs.
The researchers found that inhibiting GABA a receptor protected mice from the toxic side effects of chemotherapy or radiotherapy, reducing the amount of DNA damage and increasing the survival rate
of intestinal stem cells.
Chen and his colleagues found that inhibiting GABA a receptor protects intestinal stem cells from DNA damage
by limiting the formation of free radicals in the response to chemoradiotherapy.
Flumazenil is an inexpensive gamma aminobutyric acid a U.
"Combined, our data suggest that inhibiting GABA as a receptor is a promising strategy specifically to protect the gut from the effects of chemoradiotherapy," Chen said
.
