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Antisense Effects of PNAs in Bacteria

 Last Update: 2020-12-05
 Source: Internet
 Author: User

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pnas

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Peptide nucleic acids (PNAs) are a class of artificial
DNA
/RNA analogues that have unique physicochemical properties, whichinclude a high chemical stability, resistance to nucleases and proteases and higher mismatch sensitivity than DNA. PNAs wereinitially anticipated to be useful for application in antisense and antigene therapies; however, their poor cellular uptakehas limited their use for such purposes in the “real world”. Recently, it has been shown that the addition of metal complexesto these oligonucleotide analogues could open up new avenues for their utilization in various research fields. Such metallo-constructshave shown great promise, for a diverse range of applications, most notably in the biosensing area. In this chapter, we reporton the recent synthetic advances towards the preparation of these “(multi)-metallic PNAs” on the solid phase.

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