Antiviral therapy provides drug targets: cellular nutrition regulation.

Professor Xu Pinglong of Zhejiang University's Institute of Life Sciences team found that when cells are undernourished, the body's antiviral mechanism is more active;
findings will provide drug targets for antiviral therapy.
, according to the researchers, signaling occurs all the time inside and between cells to complete every activity of our lives.
When a virus invades a cell, certain proteins in the body's cytoste can actively detect viral nucleic acids, then activate a series of antiviral mechanisms in the cell, and send signals to surrounding cells, reminding everyone to "fight" together.
this cellular mechanism constitutes an important barrier for life to resist viruses and maintain human health.
" is like talking in human language, the 'language' of in-cell communication is a series of subjects, joint proteins, kinases, transcription factors, effect proteins and so on.
" Xu Pinglong said, cyto nucleic acid identification pathline has a key kinase "TBK1", which can induce downstream signals to promote cell synthesis of a series of antiviral factors, thereby establishing their own and surrounding cells antiviral status.
Xu Pinglong said that the team by artificially increasing or decreasing the number of cells to regulate the crowding of cells found that when the cells from crowded to loose, its antiviral capacity will decline, cell nutrition stress or crowded with each other, is conducive to improving the cell's virus defense.
study also revealed that the "Hippo path line" is a key cell mechanism for regulating cell proliferation and migration, where the level and activity of the ingredients can be used as a determinant of the intensity of the host's antiviral response.
researchers believe these groups can be used as targets for antiviral drugs.
paper was published online March 27 in the journal Nature Cell Biology.
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