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    Home > Active Ingredient News > Digestive System Information > AP&T: Bacterial mixture is better than simple fecal flora transplantation in the treatment of refractory Clostridium infection

    AP&T: Bacterial mixture is better than simple fecal flora transplantation in the treatment of refractory Clostridium infection

    • Last Update: 2021-04-22
    • Source: Internet
    • Author: User
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          medsci.
    cn">The effect of fecal bacteria transplantation in the treatment of refractory Clostridium infection has been confirmed, but there are many side effects, such as the occurrence of extra-intestinal infections.
    Therefore, some more defined bacterial mixtures may be a safer alternative to fecal microbiota transplantation (FMT).
    The purpose of this study was to compare the effects of a mixture of 12 strains of bacteria combined with FMT or vancomycin in the treatment of refractory Clostridium infection (CDI).

    medsci.
    cn">The effect of fecal bacteria transplantation in the treatment of refractory Clostridium infection has been confirmed, but there are many side effects, such as the occurrence of extra-intestinal infections.
    medsci.
    cn">Fecal Bacteria Transplant Infection

     

          The researchers screened patients with laboratory-confirmed recurrent CDI infections and pretreated them with vancomycin for 7-14 days before FMT and bacterial mixture treatment.
    Perform rectal enema therapy for three consecutive days, one enema and then FMT, and repeat this treatment 2 to 3 times within 14 days.
    The vancomycin group was treated alone for 14 days.
    The main observation outcome is the clinical cure rate within 90 days.
    The secondary result was a 180-day all-cause mortality.

     

          The results of the study showed that compared with FMT treatment, the clinical cure rate of bacterial mixture enema treatment and vancomycin treatment was higher: 45% VS 76% VS 76% (OR 3.
    9, 95% CI (1.
    4-11.
    4), P < 0.
    01), the frequency of healing is higher.
    The effects of rectal bacterial enema therapy and vancomycin were similar (P = 0.
    61).
    The mortality rate was 6% in the FMT group, 13% in the bacterial enema therapy group, and 23% in the vancomycin group.
    Compared with vancomycin, FMT has a tendency to reduce mortality (OR0.
    2 (0.
    04-1.
    12), P = 0.
    07).

     

          This study confirms that rectal bacterial enema therapy seems to be as effective as vancomycin, but FMT treatment of 1-3 enema per week is superior to vancomycin in the treatment of recurrent C.
    difficile infections and may reduce mortality.

    This study confirms that rectal bacterial enema therapy seems to be as effective as vancomycin, but FMT treatment of 1-3 enema per week is superior to vancomycin in the treatment of recurrent C.
    difficile infections and may reduce mortality.

     

     

     

    Original source:

    Anne Abildtrup Rode.
    Et al.
    wiley.
    com/doi/10.
    1111/apt.
    16309" target="_blank" rel="noopener">Randomised clinical trial: a 12-strain bacterial mixture versus faecal microbiota transplantation versus vancomycin for recurrent Clostridioides difficile infections.
    Alimentary Pharmacology & Therapeutics.
    wiley.
    com/doi/10.
    1111/apt.
    16309" target="_blank" rel="noopener">2021 .

    wiley.
    com/doi/10.
    1111/apt.
    16309" target="_blank" rel="noopener">Randomised clinical trial: a 12-strain bacterial mixture versus faecal microbiota transplantation versus vancomycin for recurrent Clostridioides difficile infections.

     



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