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    Home > Active Ingredient News > Digestive System Information > AP-T: Changes in lipid histology in obese and non-obese subjects with non-alcoholic fatty liver disease

    AP-T: Changes in lipid histology in obese and non-obese subjects with non-alcoholic fatty liver disease

    • Last Update: 2020-11-06
    • Source: Internet
    • Author: User
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    Non-alcoholic fatty liver disease (NAFLD) is caused by an abnormal accumulation of triglycerides (TGs), known as simple fatty degeneration, which can sometimes develop into non-alcoholic fatty hepatitis (NASH) and associated fibrosis.
    While excessive accumulation of triglycerides is known to be a risk factor for NAFLD, it is not clear what are the underlying mechanisms of non-obese non-alcoholic fatty hepatitis (NASH), so this study aims to try to use lipomic histological methods to determine the correlation with non-obese and obese NAFLD-related metabolic disorders.
    researchers analyzed 361 biopsy-confirmed NAFLDs (157 NAFL and 138 NASH) and health control groups (n-66).
    are classified as obese or non-obese based on Asian body mass index.
    blood lipid analysis is carried out according to the histological severity of NAFLD.
    used independent validation sets (154 NAFLD subjects (93 NAFL and 61 NASH) and 21 healthy controls) to verify cyclic lipid histological changes.
    in non-obese NAFLD patients, saturated phospholipids (SM) were significantly associated with visceral obesity (SM d38:0;P -lt;0.001), but not in obese NAFLD.
    addition, SM levels were significantly associated with insulin resistance in the whole body and adipose tissue (SM d38:0; P-lt;0.001).
    selected five potential lipid metabolites from non-obese subjects and seven potential lipids from obese subjects to predict NAFLD and NASH.
    these lipid combinations show good diagnostic performance for non-obesity (NAFLD / NASH - 0.916 / 0.813 under the curve area (AUC)) and obesity (NAFLD / NASH - 0.967 / 0.812 AUC).
    the study's final authors, non-obese and obese NAFLD subjects showed unique cyclic lipid histological characteristics, including differences in glycelin d'alipide (DAG), triglycerides (TAG) and phospholipids (SM).
    these lipid combinations may be useful biomarkers for non-obese and obese NAFLD patients.
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