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There is a correlation between trough levels of anti-tumor necrosis factor (TNF-α) drugs such as adalimumab (ADA) and infliximab (IFX) and treatment response, and lower trough concentrations can lead to primary The emergence of sexual non-response (PNR) and secondary non-response (LOR).
Figure: The relationship between anti-drug antibodies and disease response
This study confirmed that the use of drug tolerance to test anti-tumor necrosis factor anti-drug antibodies can detect the high prevalence of anti-TNF antibodies early, and their appearance indicates that the probability of stopping the drug treatment greatly increases.
Original source:
Quentin Tournier.
wiley.
com/doi/10.
1111/apt.
16333" target="_blank" rel="noopener">Early detection of anti-drug antibodies during initiation of anti-tumour necrosis factor therapy predicts treatment discontinuation in inflammatory bowel disease.
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