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    Home > Active Ingredient News > Digestive System Information > AP&T: Early detection of elevated levels of anti-drug antibodies during the initiation of anti-TNFα treatment indicates poor treatment effect

    AP&T: Early detection of elevated levels of anti-drug antibodies during the initiation of anti-TNFα treatment indicates poor treatment effect

    • Last Update: 2021-05-20
    • Source: Internet
    • Author: User
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    There is a correlation between trough levels of anti-tumor necrosis factor (TNF-α) drugs such as adalimumab (ADA) and infliximab (IFX) and treatment response, and lower trough concentrations can lead to primary The emergence of sexual non-response (PNR) and secondary non-response (LOR).


     


     


    Figure: The relationship between anti-drug antibodies and disease response


    This study confirmed that the use of drug tolerance to test anti-tumor necrosis factor anti-drug antibodies can detect the high prevalence of anti-TNF antibodies early, and their appearance indicates that the probability of stopping the drug treatment greatly increases.


     

    Original source:

    Quentin Tournier.


    wiley.
    com/doi/10.
    1111/apt.
    16333" target="_blank" rel="noopener">Early detection of anti-drug antibodies during initiation of anti-tumour necrosis factor therapy predicts treatment discontinuation in inflammatory bowel disease.


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