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    Home > Active Ingredient News > Digestive System Information > AP-T: Oral thiamine can improve fatigue symptoms in patients with inflammatory bowel disease in remission

    AP-T: Oral thiamine can improve fatigue symptoms in patients with inflammatory bowel disease in remission

    • Last Update: 2020-12-24
    • Source: Internet
    • Author: User
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    Fatigue is one of the most common symptoms in patients with inflammatory bowel disease (IBD), even in patients with IBD remission.
    of fatigue in patients with IBD during the period of remission ranged from 15% to 54%.
    women and people with Crohn's disease (CD) are more likely to develop fatigue than men and people with ulcerative colitis (UC).
    prevalence of chronic fatigue (i.e., fatigue that lasts more than six months) in patients with IBD is estimated at between 22 and 29 percent, compared with 11 percent in the health control group.
    cause of fatigue in patients with IBD or other diseases remains unclear.
    But it is generally accepted that fatigue is multi-factor, active diseases, anemia, hypothyroidism, iron, vitamin B12 or folic acid deficiency may cause IBD fatigue and should therefore be treated or corrected.
    there are few pharmacological interventions that can affect fatigue in IBD patients, and a recent non-blind study showed that high doses of oral thiamine have beneficial effects in improving fatigue.
    is essential for the use of carbohydrate and mitochondrial ATP.
    sources of thiamine are cereal products, meat, legumes and dairy products.
    of thiamine occurs in the small intestine.
    the active metabolite thiamine pyrophosphate accounts for about 80% of thiamine in the body.
    because thiamin is a water-soluble vitamin with kidney removal, the risk of thiamine accumulation is limited in patients with normal renal function.
    can be stored in the liver for up to 18 days.
    , this study aims to study the effects and safety of high doses of oral thiamine (600-1800 mg/d) based on sex and weight on chronic fatigue in patients with IBD during the period.
    study was a randomized, double-blind, placebo-controlled trial.
    patients with severe chronic fatigue in the remission period of IBD, but there is no explanation for their fatigue.
    randomly divided the patients into: 1) group: high dose of oral thiamine for 4 weeks, 4 weeks for freeing, placebo 4 weeks and 2) group: oral placebo for 4 weeks, 4 weeks for washeated.
    used inflammatory bowel disease fatigue questionnaires to measure fatigue.
    result was an improvement in fatigue after 4 weeks of taking thiamine (≥3 points).
    recruited 40 patients between November 2018 and October 2019.
    cross-analysis showed that 1) the average reduction of fatigue after thiamine was 4.5 points (95% CI 2.6-6.2), while the 2) group increased by an average of 0.75 points (95% CI -1.3-2.8; P= 0.0003)。
    addition, 75 percent of patients in group 1 showed an improvement of ≥3 points when using thiamine, while only 25 percent of patients who used a placebo showed an improvement.
    this study confirms through prospective studies that high doses of oral thiamine have a significant beneficial effect on chronic fatigue in IBD patients and are well treated.
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