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Acidophilic esophitis is a chronic esophal inflammation characterized by eosinophil immersion.
the clinical manifestations of adults are mainly difficulty swallowing, esophageal stenosis, food inset and reflow-like symptoms, some have chest bone pain, acid, heartache and other discomfort, children are mainly manifested in food rejection and malnutrition.
Perverted reactions caused by food allergies may be involved in the pathogenesis of eosinophilic esophitis, so 71 percent of patients' symptoms can be alleviated by removing specific foods from their diet, while 54 percent of endoscopic observations showed an improvement in symptoms, and dietary therapy was found to be more effective in children than in adults.
the efficacy of proton pump inhibitors (PPI) has not been reported in large-scale controlled studies, which have recently been explored in one study.
researchers followed up on patients who used proton pump inhibitors to treat acidophilitis, with clinical remission defined as a 50% reduction in the score of symptoms of dysphagia, and histological remission defined as a peak of less than 15 eosinophils per high-level field of vision.
factors related to the therapeutic effect of PPI were determined by binary logistic regression multiple analysis.
a total of 630 patients (76 children) received PPI as initial treatment, according to the results of the study at doi.org/10.1111/apt.15957.
48.8% of eosinophils with a density of less than 15 eosinophils in each high-grade field of vision after PPI treatment, and 71.0% of patients with reduced symptom scores.
PPI treatment, more EoE patients with inflammation rather than esopathic stenosis were clinically relieved (OR 3.7; 95% CI, 1.4-9.5);
the same effect can be maintained by reducing the PPI dose of 69.9% of patients with eosinophilic esophagealitis after histological remission has been achieved.
the study's final authors, PPI treatment may further promote the healing of diseases of eosinophilic esophitis.
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