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Worldwide, cirrhosis kills more than 1 million people each year, accounting for more than 2% of all deaths, and liver cell carcinoma (HCC) is the third most common cancer in the world, killing 745,000 people each year.
For decades, it has been recognized that coffee intake can prevent liver disease to some extent, and in recent years, more and more research has emerged that increasing coffee intake can not only improve the bio-chemical indicators of the liver, but also slow the development of cirrhosis.
In the largest high-quality prospective cohort study to date, Setiawan and colleagues found that people who drank two to three glasses per day had a 46 percent reduction in cirrhosis deaths, and a 71 percent reduction in cirrhosis deaths in people who drank four or more glasses a day after adjusting for major conferencing factors, including age, BMI, diabetes, gender, race, education, and alcohol consumption.
the academic community was encouraged by such encouraging data, this study also explores the relationship between coffee and liver disease mortality in terms of coffee dose.
Researchers analyzed data from the 2016 Global Burden of Disease Data On Patients Older than 15 years old, analyzed patients with more than 2 cups of coffee per day, modeled the effects of increased average coffee intake on liver-related mortality, and finally adjusted the effects of coffee doses.
2016, an estimated 1240,201 people died from liver-related diseases, according to the study.
2016, the global median liver-related mortality rate was 15 deaths/100,000 population/year (IQR: 11-21 deaths per 100,000 people).
If the total number of liver-related deaths in 2016 is expected to be 630,947, with 452,861 avoided (PPR: 7.8 liver-related deaths/100,000/year), if the average coffee intake per capita increases to 2 cups/day.
If the per capita daily consumption is 4 cups per day, liver-related deaths in 2016 are expected to be 360523 (95% CI 359825-361 992), of which 723,287 will be avoided (PPR: 12.1 liver-related deaths/10000/year).
The study has confirmed the effects of coffee on liver-related mortality, and an increase in per capita coffee consumption to more than two cups a day in terms of population could prevent thousands of liver-related deaths each year, the researchers said.
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