AP-T: Trace element deficiency in patients with alcoholic hepatitis is associated with infection and death.

!---- Background malnutrition is common in patients with alcohol-related liver disease and is associated with outcomes in patients with alcoholic hepatitistrace elements (cobalt, copper, iron, selenium and zinc) are essential for many cellular activities, including antioxidant pathwaysThe prevalence and correlation of trace element deficiency inalcohol-related hepatitis is not clearstudy to determine the prevalence of trace element deficiency in patients with alcoholic hepatitis and its relationship to clinical outcomesmethod researchers obtained the required serum samples from alcoholic hepatitis, alcohol-related cirrhosis and healthy volunteersthe concentration ofelements is measured by inductively coupled plasma mass spectrometrythe multifactory logistic regression assessment of the association between trace element levels and the development of infection within 90 days and mortality rates within 28 and 90 daysresults This study analyzed the serum concentration of trace elements in 302 patients with alcoholic hepatitis, 46 patients with alcohol-related cirrhosis and 15 healthy controlsthe prevalence of zinc deficiency (85%) and selenium deficiency (67%) of alcoholic hepatitis was higher than that of alcohol-related cirrhosis (72% (p s.04; 37% (p-lt;0.001)is significantly different between the two groups of zinc, selenium, copper and chromiumiron deficiency is a predicted indicator of infection development within 90 dayszinc deficiency is a predicted indicator of mortality over a period of 28 and 90 daysconcluded that trace element deficiency is very common in patients with alcoholic hepatitis and is associated with infection and deathsupplementation of selected trace elements may improve the clinical outcome of the patient group.