App Envir Micro: a potential antidote for botulism

Botulinum neurotoxins (BoNTs) are known human proteins toxic to most, was synthesized from seven different strains of anaerobic bacteria species (serotypes A to G) immunized distinct family of proteins
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, Its long-lasting paralysis, extreme toxicity, easy production and lack of antidote, make BoNTs a first-level biological threat agent

In this study, the researchers’ first step was to identify the enzymes in the botulinum neurotoxin that damage neurons and cause paralysis

Nitrobenzene psoralen (3- (.
4-nitrophenyl) -7H-Furo [.

In order to better understand the effect of NPP on BOT/A-mediated muscle paralysis, the researchers stimulated the isolated mouse diaphragmatic phrenic nerve at a frequency of 0.

The time course of BOT/A- mediated muscle inhibition of mouse diaphragm contraction tension is 0.

03 Hz

BOT / A time course mediated inhibition of mouse diaphragm muscles shrink tension of 0.

diagnosis

These studies show that natural compounds have the potential to become effective botulinum inhibitors
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In the United States, psoralen-derived drugs have been approved by the FDA, which is likely to speed up the NPP drug approval process

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These studies show that natural compounds have the potential to become effective botulinum inhibitors

Article reference: Kruti B.

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