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Molecular models show that dCas9 binds to the guide RNA-RNA origami fusion molecule, bringing transcription factors into the promoter sequence
The development of tools for precise control of biological processes has been one of the main pillars of the now mature field of
However, an RNA structure design method recently developed by Anderson's lab called "RNA origami" is trying to solve this problem
RNA sponges regulate the production of enzymes in bacteria
In the first method, RNA origami is used to achieve precise control
CRISPR-based yeast chemical plant regulator
In the second method, RNA origami is combined with CRISPR, one of the most popular modern molecular biology techniques, to regulate gene expression
Utilizing RNA origami scaffolds in Saccharomyces cerevisiae for dCas9-mediated transcriptional control