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Intracebral hemorrhage (ICH) is the second most common stroke subtype, with a 5-year survival rate of 29%, and only 12% of survivors achieve long-term functional independence
The 5-year survival rate is 29%, and only 12% of survivors achieve long-term functional independence.
Neurotoxic mechanisms of acute brain injury after ICH :
Therefore, it is necessary to understand the mechanism of brain injury after intracerebral hemorrhage and to develop drugs to prevent and treat intracerebral hemorrhage
It is necessary to understand the mechanism of brain injury after intracerebral hemorrhage, to develop drugs for prevention and treatment of intracerebral hemorrhage.
Inflammatory response mechanism of brain injury after ICH:
Mechanisms of the BBB in brain injury after ICH:
Mechanisms of the BBB in brain injury after ICH:At present, the medicinal materials ( salvia, sanqi, leech, musk, borneol, peach kernel, rhubarb , etc.
Relieves BBB permeability and brain edema by inhibiting neuroinflammation , OS damage and apoptosis and potential mechanisms of cell death ① multiple downstream targets mediated by TLRs (MyD88, TRAF6, NF-κB, NLRP3); ② Nrf2-mediated anti-oxidative effect; ③ PI3K/Akt-mediated anti-apoptotic effect; Apoptosis; mTOR-mediated autophagy
It is beneficial to explore specific drug targets and mechanisms of action, to determine the compatibility of actual components of traditional Chinese medicine, and to evaluate the dosage form and route of administration of traditional Chinese medicine
Future research may focus on herbal medicines targeting VEGF, BDNF, Wnt signaling pathway and NSC, which may shed light on the potential mechanism of TCM in nerve regeneration and functional recovery
ICH is a pathological process involving multiple targets and systems.
In the future, intervention strategies such as integrative medicine will make new progress in the treatment of ICH
Original text: Duan T, Li L, Yu Y, Li T, Han R, Sun X, Cui Y, Liu T, Wang X, Wang Y, Fan X, Liu Y, Zhang H.
Original text: Duan T, Li L, Yu Y, Li T, Han R, Sun X, Cui Y, Liu T, Wang X, Wang Y, Fan X, Liu Y, Zhang H.
Traditional Chinese medicine use in the pathophysiological processes of intracerebral hemorrhage and comparison with conventional therapy.
Pharmacol Res.
2022 Mar 31;179:106200.
doi: 10.
1016/j.
phrs.
2022.
106200.
Epub ahead of print.
PMID: 35367344.
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