Application prospect of polymer materials in pharmaceutical blister packaging

At present, the application share of polymer packaging (plastic packaging) in the market is increasing day by day In the future, the general trend of the packaging development of drug polymer materials is: from container application to composite soft packaging materials to occupy and dominate the market Nowadays, the development of high polymer materials used in drug soft packaging in China is very rapid, with the continuous emergence of new materials With the continuous improvement of people's understanding of the materials to be used, the polymer materials have also been updated For example, the foamed flexible packaging base material PVC, which is widely used in the market, belongs to the amorphous polymer Its main characteristic in processing and application is that it has no obvious melting point, and it is plastic when heated to 120 ℃ - 150 ￣ 2 Because of its poor thermal stability, it is easy to be heated An alkaline stabilizer must be added to neutralize hydrogen chloride, so as to inhibit its autocatalytic cracking reaction Generally speaking, PVC has the advantages of chemical resistance, wear resistance, flame resistance, self extinguishing, high strength, electrical insulation, barrier, low price and wide sources The rigid PVC sheet used for drug blister packaging is made of PVC resin and some processing aids It can be extruded and calendered to produce products that meet the requirements of medicine As the base material of blister packaging, it can separate each tablet, pill and capsule independently, making it a small drug packaging unit of Zui The accuracy and safety of using drugs are greatly improved The processing method is simple, small investment, easy to process and shape, which makes the production cost of pharmaceutical enterprises reduce and the production efficiency greatly improve From the initial stage of application to now, most pharmaceutical enterprises choose this material to package tablets, pills and capsules In the 1990s, the original PVC rigid film packaging drugs had poor performance of water vapor barrier Therefore, it is not suitable for drug packaging with moisture-proof and vapor proof requirements, especially for pill, powder and particle packaging of traditional Chinese medicine products, which are more sensitive to the requirements of water vapor and humidity, and packaging materials should be carefully selected In addition, in the long-term processing and use of PVC, people realize that it has a negative impact on human living environment and organism When PVC polymerized monomers, VCM will be produced In the process of burning PVC products, dioxin hydrochloride is produced The hydrogen chloride produced after decomposition pollutes the living environment Its monomer, plasticizer and stabilizer will have a serious impact on human body and environment In developed countries, such as Germany, pharmaceutical manufacturers no longer use PVC as blister packaging, and Japan also limits the production of PVC products PVC as blister packaging materials is about to face a new generation It is urgent to choose new high polymer packaging materials to protect the use and safety of drugs 1 Drug blister packaging high barrier new polymer material 1.1 polyvinylidene chloride packaging material (PVDC) The homopolymer of vinylidene chloride, polyvinylidene chloride, is difficult to be processed Although it has very outstanding gas barrier performance, it cannot be industrialized Therefore, PVDC is generally referred to as the copolymerized polymer material with vinylidene chloride (VDC) as the main body The VDC content of PVDC used in drug packaging is about 90%, and the monomers often used are acrylic acid, acrylate, etc These comonomers play the role of internal plasticization, improve the processing performance of PVDC, and at the same time, their barrier performance has not been seriously reduced The processing industry of PVDC began in the late 1930s It was first produced by Dow Chemical Company in the United States At that time, it was "World War II" PVDC was mainly used for military packaging After that, with the rapid development of the world industry, PVDC has shown excellent performance in the quality assurance and shelf life extension of drugs and food Therefore, the leading position of PVDC as a high barrier material has never been weakened in recent decades The outstanding function of drug packaging materials lies in the selection of barrier performance PVDC has a high polymer density, regular structure and high crystallinity, so it has excellent performance It has excellent gas sealing performance, moisture resistance and steam resistance, good oil resistance, drug resistance and solvent resistance Due to the copolymerization modification, PVDC can not only co extrude and composite, but also blow film, so as to composite with other materials, forming a composite soft packaging material with excellent barrier performance.