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In March 2022, the team of Professor Li Bin of Jinan University discovered that Penfluridol , an antipsychotic clinical drug, can significantly inhibit the growth of esophageal cancer based on the strategy of "reuse of old drug.
Penfluridol
To search for drugs that could treat esophageal cancer from existing drugs, the researchers screened a small-molecule library of 1320 FDA -approved drugs (Figure 1.
FDA
Penfluidol Chemical Structure
Figure 1 Screening of esophageal cancer drug penfluidol
Figure 1 Screening of esophageal cancer drug penfluidolSubsequently, using the Drug Affinity Response Target Stability ( DARTS ) technique (F.
Drug Affinity Response Target Stability Drug Affinity Response Target Stability ( ( DARTS DARTS ) ) Technology Technology Phosphofructokinase (PFKL)
Figure 2 Determination and validation of the drug target of penfluridol
Figure 2 Determination and validation of the drug target of penfluridolIn conclusion, the study identified penfluidol as a novel anticancer drug by screening 1320 FDA-approved dru.
The direct binding of penflulidol to PFKL can inhibit the glycolysis of esophageal cancer cells and activate the AMPK/FOXO3a/BIM signaling pathway, thereby inhibiting the occurrence of tumor.
Figure 3 Penfluidol targeting PFKL to inhibit the model of esophageal cancer
Figure 3 Penfluidol targeting PFKL to inhibit the model of esophageal cancerIn fact, there have been many studies on Penfluridol in recent yea.
stem cellcolorectal cancer
Mays believes that the mechanism of action of antipsychotic drugs may be quite complicat.
Original source:
Zheng C, Yu X, Liang Y, Zhu Y, He Y, Liao L, Wang D, Yang Y, Yin X, Li A, He Q, Li.
Zheng C, Yu X, Liang Y, Zhu Y, He Y, Liao L, Wang D, Yang Y, Yin X, Li A, He Q, Li.
Tung MC, Lin YW, Lee WJ, Wen YC, Liu YC, Chen JQ, Hsiao M, Yang YC, Chien .
Wang NN, Zhang PZ, Zhang J, Wang HN, Li L, Ren F, Dai PF, Li H, Lv .
Xue Q, Liu Z, Feng Z, Xu Y, Zuo W, Wang Q, Gao T, Zeng J, Hu X, Jia F, Zhu Y, Xia Y, Yu.
Penfluridol : An antipsychotic agent suppresses lung cancer cell growth and metastasis by inducing G0/G1 arrest and apoptos.
Xue Q, Liu Z, Feng Z, Xu Y, Zuo W, Wang Q, Gao T, Zeng J, Hu X, Jia F, Zhu Y, Xia Y, Yu.
Penfluridol : An antipsychotic agent suppresses lung cancer cell growth and metastasis by inducing G0/G1 arrest and apoptos.
Penfluridol Biomed Pharmacoth.
2020 Jan;121:10959 doi: 11016.
biop.
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