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    Home > Active Ingredient News > Antitumor Therapy > APS: The antipsychotic penfluidol targets PFKL to inhibit the growth of esophageal cancer and may have broad antitumor effects

    APS: The antipsychotic penfluidol targets PFKL to inhibit the growth of esophageal cancer and may have broad antitumor effects

    • Last Update: 2022-08-12
    • Source: Internet
    • Author: User
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    In March 2022, the team of Professor Li Bin of Jinan University discovered that Penfluridol , an antipsychotic clinical drug, can significantly inhibit the growth of esophageal cancer based on the strategy of "reuse of old drug.


    Penfluridol

    To search for drugs that could treat esophageal cancer from existing drugs, the researchers screened a small-molecule library of 1320 FDA -approved drugs (Figure 1.


    FDA

    Penfluidol Chemical Structure

     

    Figure 1 Screening of esophageal cancer drug penfluidol

    Figure 1 Screening of esophageal cancer drug penfluidol

    Subsequently, using the Drug Affinity Response Target Stability ( DARTS ) technique (F.


    Drug Affinity Response Target Stability Drug Affinity Response Target Stability ( ( DARTS DARTS ) ) Technology Technology Phosphofructokinase (PFKL)

    Figure 2 Determination and validation of the drug target of penfluridol

    Figure 2 Determination and validation of the drug target of penfluridol

    In conclusion, the study identified penfluidol as a novel anticancer drug by screening 1320 FDA-approved dru.


    The direct binding of penflulidol to PFKL can inhibit the glycolysis of esophageal cancer cells and activate the AMPK/FOXO3a/BIM signaling pathway, thereby inhibiting the occurrence of tumor.


    Figure 3 Penfluidol targeting PFKL to inhibit the model of esophageal cancer

    Figure 3 Penfluidol targeting PFKL to inhibit the model of esophageal cancer

    In fact, there have been many studies on Penfluridol in recent yea.


    stem cellcolorectal cancer

    Mays believes that the mechanism of action of antipsychotic drugs may be quite complicat.


    Original source:

    Zheng C, Yu X, Liang Y, Zhu Y, He Y, Liao L, Wang D, Yang Y, Yin X, Li A, He Q, Li.


    Zheng C, Yu X, Liang Y, Zhu Y, He Y, Liao L, Wang D, Yang Y, Yin X, Li A, He Q, Li.


    Tung MC, Lin YW, Lee WJ, Wen YC, Liu YC, Chen JQ, Hsiao M, Yang YC, Chien .


    Wang NN, Zhang PZ, Zhang J, Wang HN, Li L, Ren F, Dai PF, Li H, Lv .


    Xue Q, Liu Z, Feng Z, Xu Y, Zuo W, Wang Q, Gao T, Zeng J, Hu X, Jia F, Zhu Y, Xia Y, Yu.
    Penfluridol : An antipsychotic agent suppresses lung cancer cell growth and metastasis by inducing G0/G1 arrest and apoptos.
    Xue Q, Liu Z, Feng Z, Xu Y, Zuo W, Wang Q, Gao T, Zeng J, Hu X, Jia F, Zhu Y, Xia Y, Yu.
    Penfluridol : An antipsychotic agent suppresses lung cancer cell growth and metastasis by inducing G0/G1 arrest and apoptos.
    Penfluridol Biomed Pharmacoth.
    2020 Jan;121:10959 doi: 11016.
    biop.
    201109598 Leave a message here
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