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APS: Wogonin protects glomerular podocytes by targeting BCL-2 mediated autophagy and apoptosis.

 Last Update: 2021-10-10
 Source: Internet
 Author: User

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Diabetic nephropathy (DKD) is one of the microvascular complications of diabetes and the main cause of end-stage renal disease, with limited treatment options
.

Wogonin is a flavonoid compound extracted from the root of Scutellaria baicalensis Georgi, which has a strong renal protective effect

Wogonin

Results: Wogonin(4,8,16 μ M) dose-dependently reduce the high glucose (HG) MPC5 induced cell damage, and increases with WT-1, nephrin and podocin protein, TNF-α, MCP -1, IL-1β and phosphorylated P65 expression decreased
.

In addition, wogonin can significantly inhibit MPC5 cell apoptosis induced by HG

Wogonin wogonin wogonin wogonin wogonin wogonin wogonin ^{-.

The effect of wogonin on the viability of MPC5 cells treated with high glucose and its inhibitory effect on inflammation induced by high glucose
.

a.

The effect of wogonin on the viability of MPC5 cells treated with high glucose and its inhibitory effect on inflammation induced by high glucose

Wogonin promotes HG-induced autophagy disorder
.

b Western blot analysis of the expression of beclin-1, ATG7, LC3 and p62 in MPC5 cells

Wogonin promotes HG-induced autophagy disorder

Bcl-2 overexpression and wogonin have similar cytoprotective effects
.

Real-time PCR analysis of Bcl-2 in MPC5 cells

Bcl-2 overexpression and wogonin have similar cytoprotective effects

This study confirmed for the first time the new role of wogonin in alleviating glomerular pathology and podocyte damage by regulating Bcl-2 to mediate autophagy and apoptosis

Liu XQ, Jiang L, Li YY,et al, Wogonin protects glomerular podocytes by targeting Bcl-2-mediated autophagy and apoptosis in diabetic kidney disease .
Acta Pharmacol Sin 2021 Jul 12;
Wogonin protects glomerular podocytes by targeting Bcl- 2-mediated autophagy and apoptosis in diabetic kidney disease in this message}

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