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OBJECTIVE : To assess the incidence and risk factors of breakthrough COVID-19 infection in a cohort of vaccinated patients with autoimmune rheumatic diseases (AIRDs) and to determine whether antibodies to the receptor-binding domain (anti-RBD) of the spike protein may act as a A reliable predictor of susceptibility to such infection.
OBJECTIVE : To assess the incidence and risk factors of breakthrough COVID-19 infection in a cohort of vaccinated patients with autoimmune rheumatic diseases (AIRDs) and to determine whether antibodies against the receptor-binding domain (anti-RBD) of the spike protein as a reliable predictor of susceptibility to such infection.
Methods : AIRD patients who completed two doses of SARS-CoV2 vaccine were included, and anti- RBD antibodies were measured 4-6 weeks after the second dose of vaccine , and they were divided into good responders (GR) (>212 IU) and insufficient responde.
Methods AIRD patients who completed two doses of SARS-CoV2 vaccine were enrolled, and anti- RBD antibodies were measured 4-6 weeks after the second dose of vaccine , and they were divided into good responders (GR) (>212 IU) and insufficient responders ( IR) (8 – 212 IU) and non-responders (NR) (<8 IU.
RESULTS: A total of 630 patients with AIRD (mean age , 52 ( ± 16) years, male to female ratio, 1:2 ) were studi.
Breakthrough infection occurred in 47 patients (4%) with a mean follow-up time of 143 ( ± 57) days, with the highest proportion in the NR group (19; 175%) , followed by the IR group (13; 09%) and the GR group the least ( 15 ; 95%.
CONCLUSIONS: Breakthrough infection occurred in 4% of patients and was associated with seronegative post-vaccinati.
Source: Ahmed S, Mehta P, Paul A , et a.
Ahmed S, Mehta P, Paul A , et a.
Postvaccination antibody titres predict protection against COVID-19 in patients with autoimmune diseases: survival analysis in a prospective coho.
Annals of the Rheumatic Diseases2022; 81: 868-87 , et al Annals of the Rheumatic Diseases81: Leave a comment here
