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    Home > Active Ingredient News > Immunology News > ARD: B cell depletion impairs the CD8+ T cell response induced by vaccination in a type I interferon-dependent manner

    ARD: B cell depletion impairs the CD8+ T cell response induced by vaccination in a type I interferon-dependent manner

    • Last Update: 2022-01-07
    • Source: Internet
    • Author: User
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         Objective: monoclonal anti- CD20 antibody rituximab is often used in the treatment of lymphoma and self- immune diseases, can effectively remove circulating B cells
    .
    Accordingly, during
    infection or vaccination,
    patients with depleted B cells hardly develop de novo antibody responses
    .
    Therefore,
    the effective immune response of patients with B cell depletion depends largely on the protective T cell response
    .

         Objective: monoclonal anti- CD20 antibody rituximab is often used in the treatment of lymphoma and self- immune diseases, can effectively remove circulating lymphoma immune B cells
    .
    Accordingly, the
    infection during or vaccination,
    infection of B cells in patients with depleted hardly generated de novo antibody response
    .
    Therefore,
    the effective immune response of patients with B cell depletion depends largely on the protective T cell response
    .

         Methods: CD8+ T cell expansion was studied in rituximab-treated rheumatoid arthritis (RA) patients and B- cell deficient mice that were vaccinated / infected with different vaccines / pathogens .

         Methods: CD8+ T cell expansion was studied in rituximab-treated rheumatoid arthritis (RA) patients and B- cell deficient mice , these mice were vaccinated / infected with different vaccines / Pathogen .

         Results: Compared with healthy controls, patients with RA who received rituximab were vaccinated with Influvac vaccine, and the expansion of influenza-specific CD8+ T cells was reduced .
    In addition, compared with wild-type mice, B- cell-deficient JHT mice infected with mouse-adapted influenza or modified vaccinia virus Ankara showed reduced expansion of virus-specific CD8+ T cells .
    It is worth noting that JHT mice do not have the inherent damage of CD8+ T cell expansion, because vaccinia virus infection induces similar T cell expansion in JHT and wild-type mice .
    B Direct cells I interferon receptor signaling for the induction B of several cells by enhancing chemokines and MHC-I to support the expression of T cell help is needed .




         Results: Compared with healthy controls, patients with RA who received rituximab were vaccinated with Influvac vaccine, and the expansion of influenza-specific CD8+ T cells was reduced .
    In addition, compared with wild-type mice, B- cell-deficient JHT mice infected with mouse-adapted influenza or modified vaccinia virus Ankara showed reduced expansion of virus-specific CD8+ T cells .
    It is worth noting that JHT mice do not have the inherent damage of CD8+ T cell expansion, because vaccinia virus infection induces similar T cell expansion in JHT and wild-type mice .
    B Direct cells I interferon receptor signaling for the induction B of several cells by enhancing chemokines and MHC-I to support the expression of T cell help is needed .




          Conclusion: According to different stimuli, B cells can regulate the response of CD8+ T cells
    .
    Therefore,
    B cell depletion leads to a lack of de novo antibody response and affects the efficacy of cellular responses including cytotoxic T cells
    .
    It is necessary to reassess the
    selection of suitable vaccination for patients with B cell depletion to effectively induce a protective CD8+ T cell response
    .
     

          Conclusion: According to different stimuli, B cells can regulate the response of CD8+ T cells
    .
    Therefore,
    B cell depletion leads to a lack of de novo antibody response and affects the efficacy of cellular responses including cytotoxic T cells
    .
    It is necessary to reassess the
    selection of suitable vaccination for patients with B cell depletion to effectively induce a protective CD8+ T cell response
    .
     

    Source: Graalmann T, Borst K, Manchanda H , et al .
    B cell depletion impairs vaccination-induced CD8
    +  T cell responses in a type I interferon-dependent manner.
    Annals of the Rheumatic Diseases  2021; 80: 1537-1544.

    Source: Graalmann T, Borst K, Manchanda H , et al .
    B cell depletion impairs vaccination-induced CD8
    +  T cell responses in a type I interferon-dependent manner.
    Annals of the Rheumatic Diseases  2021; 80: 1537-1544.
    , et al + Annals of the Rheumatic Diseases  80:

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