Objective: monoclonal anti- CD20 antibody rituximab is often used in the treatment of lymphoma and self- immune diseases, can effectively remove circulating B cells
.
Accordingly, during infection or vaccination, patients with depleted B cells hardly develop de novo antibody responses
.
Therefore, the effective immune response of patients with B cell depletion depends largely on the protective T cell response
.
.
Accordingly, the infection during or vaccination, infection of B cells in patients with depleted hardly generated de novo antibody response
.
Therefore, the effective immune response of patients with B cell depletion depends largely on the protective T cell response
.
Methods: CD8+ T cell expansion was studied in rituximab-treated rheumatoid arthritis (RA) patients and B- cell deficient mice that were vaccinated / infected with different vaccines / pathogens .
Results: Compared with healthy controls, patients with RA who received rituximab were vaccinated with Influvac vaccine, and the expansion of influenza-specific CD8+ T cells was reduced .
In addition, compared with wild-type mice, B- cell-deficient JHT mice infected with mouse-adapted influenza or modified vaccinia virus Ankara showed reduced expansion of virus-specific CD8+ T cells .
It is worth noting that JHT mice do not have the inherent damage of CD8+ T cell expansion, because vaccinia virus infection induces similar T cell expansion in JHT and wild-type mice .
B Direct cells I interferon receptor signaling for the induction B of several cells by enhancing chemokines and MHC-I to support the expression of T cell help is needed .
In addition, compared with wild-type mice, B- cell-deficient JHT mice infected with mouse-adapted influenza or modified vaccinia virus Ankara showed reduced expansion of virus-specific CD8+ T cells .
It is worth noting that JHT mice do not have the inherent damage of CD8+ T cell expansion, because vaccinia virus infection induces similar T cell expansion in JHT and wild-type mice .
B Direct cells I interferon receptor signaling for the induction B of several cells by enhancing chemokines and MHC-I to support the expression of T cell help is needed .
Conclusion: According to different stimuli, B cells can regulate the response of CD8+ T cells
.
Therefore, B cell depletion leads to a lack of de novo antibody response and affects the efficacy of cellular responses including cytotoxic T cells
.
It is necessary to reassess the selection of suitable vaccination for patients with B cell depletion to effectively induce a protective CD8+ T cell response
.
.
Therefore, B cell depletion leads to a lack of de novo antibody response and affects the efficacy of cellular responses including cytotoxic T cells
.
It is necessary to reassess the selection of suitable vaccination for patients with B cell depletion to effectively induce a protective CD8+ T cell response
.
Source: Graalmann T, Borst K, Manchanda H , et al .
B cell depletion impairs vaccination-induced CD8 + T cell responses in a type I interferon-dependent manner.
Annals of the Rheumatic Diseases 2021; 80: 1537-1544.
B cell depletion impairs vaccination-induced CD8 + T cell responses in a type I interferon-dependent manner.
Annals of the Rheumatic Diseases 2021; 80: 1537-1544.
, et al + Annals of the Rheumatic Diseases 80:
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