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Objective: Systemic lupus erythematosus ( SLE ) is a typical systemic autoimmune disease
.
Although long-term prognosis has greatly improved, better long-term survival is still needed
Objective: Systemic lupus erythematosus ( SLE ) is a typical systemic autoimmune disease
Methods: We classified 19 immune cell subsets and identified mRNA expression profiles and genetic polymorphisms in 107 SLE patients and 92 healthy controls .
Combining differentially expressed genes and expressed quantitative trait loci analysis, we searched for key driver genes in the pathogenesis of SLE .
Results: We uncovered the transcriptomic, epigenetic and genetic importance of oxidative phosphorylation (OXPHOS)/ mitochondrial dysfunction in SLE memory B cells .
In particular, the researchers identified an OXPHOS - regulated gene , PRDX6 ( peroxidoreductin 6 ), as a key driver of SLE B cells .
Prdx6- deficient B cells show upregulation of mitochondrial respiration as well as antibody production .
RESULTS: Transcriptomic, epigenetic and genetic importance of oxidative phosphorylation (OXPHOS)/ mitochondrial dysfunction in SLE memory B cells was discovered .
In particular, an OXPHOS - regulated gene , PRDX6 ( peroxidoreductin 6 ), was identified as a key driver of SLE B cells .
Prdx6- deficient B cells show upregulation of mitochondrial respiration as well as antibody production .
The OXPHOS signature correlates with the signature of type I IFN signaling-related genes (ISRGs) in SLE memory B cells .
In addition, genes associated with innate immune signaling in ISRGs were associated with OXPHOS , two features shown to correlate withSLE organ damage as well as specific clinical phenotypes .
Conclusions: This work elucidates potential prognostic markers in systemic lupus erythematosus
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Since OXPHOS consists of the electron transport chain, a functional unit in mitochondria, these findings suggest the importance of mitochondrial dysfunction as a key immune pathway involved in SLE .
Conclusions: This work elucidates potential prognostic markers in systemic lupus erythematosus
Source: Takeshima Y, Iwasaki Y, Nakano M , et al.
Immune cell multiomics analysis reveals contribution of oxidative phosphorylation to B-cell functions and organ damage of lupus.
Annals of the Rheumatic Diseases Published Online First: 02 March 2022.
doi: 10.
1136 /annrheumdis-2021-221464Source: Takeshima Y, Iwasaki Y, Nakano M , et al.
, et al.
Immune cell multiomics analysis reveals contribution of oxidative phosphorylation to B-cell functions and organ damage of lupus.
Annals of the Rheumatic Diseases Annals of the Rheumatic Diseases Published Online First: 02 March 2022.
doi: 10.
1136/annrheumdis-2021-221464Leave a message here