echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Immunology News > ARD: Immune Cell Multi-omics Analysis Reveals the Role of Oxidative Phosphorylation on Lupus B Cell Function and Organ Damage

    ARD: Immune Cell Multi-omics Analysis Reveals the Role of Oxidative Phosphorylation on Lupus B Cell Function and Organ Damage

    • Last Update: 2022-04-17
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    Objective: Systemic lupus erythematosus ( SLE ) is a typical systemic autoimmune disease
    .


    Although long-term prognosis has greatly improved, better long-term survival is still needed


    Objective: Systemic lupus erythematosus ( SLE ) is a typical systemic autoimmune disease


    Methods: We classified 19 immune cell subsets and identified mRNA expression profiles and genetic polymorphisms in 107 SLE patients and 92 healthy controls .
    Combining differentially expressed genes and expressed quantitative trait loci analysis, we searched for key driver genes in the pathogenesis of SLE .

    Results: We uncovered the transcriptomic, epigenetic and genetic importance of oxidative phosphorylation (OXPHOS)/ mitochondrial dysfunction in SLE memory B cells .


    In particular, the researchers identified an OXPHOS - regulated gene , PRDX6 ( peroxidoreductin 6 ), as a key driver of SLE B cells .
    Prdx6- deficient B cells show upregulation of mitochondrial respiration as well as antibody production .


    RESULTS: Transcriptomic, epigenetic and genetic importance of oxidative phosphorylation (OXPHOS)/ mitochondrial dysfunction in SLE memory B cells was discovered .
    In particular, an OXPHOS - regulated gene , PRDX6 ( peroxidoreductin 6 ), was identified as a key driver of SLE B cells .
    Prdx6- deficient B cells show upregulation of mitochondrial respiration as well as antibody production .
    The OXPHOS signature correlates with the signature of type I IFN signaling-related genes (ISRGs) in SLE memory B cells .
    In addition, genes associated with innate immune signaling in ISRGs were associated with OXPHOS , two features shown to correlate withSLE organ damage as well as specific clinical phenotypes .

          Conclusions: This work elucidates potential prognostic markers in systemic lupus erythematosus
    .


    Since OXPHOS consists of the electron transport chain, a functional unit in mitochondria, these findings suggest the importance of mitochondrial dysfunction as a key immune pathway involved in SLE .


          Conclusions: This work elucidates potential prognostic markers in systemic lupus erythematosus


     

    Source: Takeshima Y, Iwasaki Y, Nakano M , et al.


    Immune cell multiomics analysis reveals contribution of oxidative phosphorylation to B-cell functions and organ damage of lupus.
    Annals of the Rheumatic Diseases  Published Online First: 02 March 2022.
    doi: 10.
    1136 /annrheumdis-2021-221464

    Source: Takeshima Y, Iwasaki Y, Nakano M , et al.
    , et al.
    Immune cell multiomics analysis reveals contribution of oxidative phosphorylation to B-cell functions and organ damage of lupus.
    Annals of the Rheumatic Diseases  Annals of the Rheumatic Diseases  Published Online First: 02 March 2022.
    doi: 10.
    1136/annrheumdis-2021-221464Leave a message here
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.