ARD: The short-term dose and duration-dependent risk of cardiovascular events of glucocorticoids in patients with rheumatoid arthritis initially treated with glucocorticoids

Objective : Rheumatoid arthritis (RA) and the use of corticosteroids and cardiac vascular diseases
.

The cardiovascular safety of glucocorticoids in RA is controversial, which may be related to the dosage and duration of use

Objective : rheumatoid arthritis (RA) and the use of corticosteroids and cardiac vascular diseases

Methods : included CorEvitas (formerly known as CORRONA ) RA patients registered

Results : 19 902 patients met the criteria

Conclusion : In the previous 6 months and 1 year intervals, after the RA patients who did not use glucocorticoids started to use glucocorticoids, the daily dose ≥ 5 mg , the cumulative dose and the duration of use increased were related to the increased risk of CVE .
Daily prednisone ≤ 4 mg or less cumulative dose and shorter duration are not related to the risk of CVE .

 

Source:

Ocon AJ, Reed G, Pappas DA , et al .

Short-term dose and duration-dependent glucocorticoid risk for cardiovascular events in glucocorticoid-naive patients with rheumatoid arthritis.
Annals of the Rheumatic Diseases2021; 80: 1522-1529.

Ocon AJ, Reed G, Pappas DA , et al .
Short-term dose and duration-dependent glucocorticoid risk for cardiovascular events in glucocorticoid-naive patients with rheumatoid arthritis.
Annals of the Rheumatic Diseases2021; 80: 1522-1529.
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