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▎The content team editor of WuXi AppTec.
Since many new crown vaccines were approved and put into mass vaccination around the world, there have been more and more data to support the true protective effect of these vaccines.
At the same time, safety is always an important aspect of people's attention.
The Journal of the American Medical Association recently published a study from Massachusetts General Hospital that introduced the incidence of acute allergic reactions after nearly 65,000 medical staff were vaccinated with the mRNA new crown vaccine.
Screenshot source: JAMA This study included 64,900 hospital employees who received the first dose of mRNA COVID-19 vaccine between December 16, 2020 and February 12, 2021, of which 25,929 (40%) received the Pfizer/BioNTech vaccine.
38971 people (60%) received the Moderna vaccine.
The research team followed them until February 18, 2021.
Within 3 days of vaccination, 52,805 people (81%) completed at least one symptom survey.
Investigation methods include emails, text messages, phone calls, mobile apps, etc.
Acute allergic reaction symptoms include itching, rash, hives, swelling and/or respiratory symptoms.
The research team pointed out that since the subjects are medical staff, the reliability of the self-reported data is high.
In order to more accurately identify severe allergic reactions (anaphylaxis), the research team asked allergists or immunologists to review health records, and the final confirmed severe allergic reactions need to meet Brighton standards or NIAID/FAAN (National Institute of Allergy and Infectious Diseases/ At least one of the Food Allergy and Allergic Response Network) standards.
Image source: A total of 1,365 people (2.
10%) from 123RF reported acute allergic reactions.
The proportion of Pfizer/BioNTech vaccinators was 1.
95%, and the proportion of Moderna vaccinators was 2.
20%.
Severe allergic reactions (0.
025%) were confirmed in 16 people, including 7 patients (0.
027%) who received Pfizer/BioNTech new crown vaccine, and 9 patients (0.
023%) who received Moderna new crown vaccine.
People with severe allergic reactions are 41 years old on average, 15 people (94%) are women, 10 people (63%) have a history of allergies, and 5 people (31%) have a history of severe allergies.
The average time for a severe allergic reaction (after vaccination) is 17 minutes (range: 1 minute-120 minutes).
One patient received intensive care, and 9 patients (56%) received intramuscular adrenaline therapy.
All patients with severe allergic reactions recovered without shock or need for intubation.
In addition, 3 patients with severe allergies who had a history of severe allergies did not seek treatment.
Image source: 123RF research team pointed out that in this study of medical staff, nearly 98% of people did not have any symptoms of allergic reactions after vaccinating the mRNA new crown vaccine, and the incidence of severe allergic reactions was 2.
47 cases per 10,000 doses of vaccination.
.
Moreover, most people with severe allergic reactions have a history of allergies.
At the same time, from another perspective, considering that about 5% of adults have a history of severe food allergies and 1% have a history of severe drug allergies, this means that among these medical staff, nearly 4000 have severe food or drug allergies People in history have been vaccinated safely.
In summary, the research team believes that although the incidence of this severe allergic reaction is higher than the rate calculated by the CDC based on passive spontaneous reports (0.
025-0.
11 cases per 10,000 doses of vaccination), it is severely allergic to the mRNA new crown vaccine The overall risk is still very low, roughly equivalent to other common medical exposure risk levels. Related readings on new crown research In June this year, China's vaccination rate is planned to reach 40%.
One article sees that a number of new crown vaccines have been approved across China.
Is the vaccine still useful? Two "The Lancet" shows a strong immune response! Real-world data on AstraZeneca's new crown vaccine was released for the first time.
One shot significantly reduced elderly illnesses and hospitalizations, reducing 92% of new crown infections and 94% of cases.
NEJM published two articles about 600,000 people receiving Pfizer/BioNTech vaccine data in Israel.
NEJM: Targeting multiple How effective are the key variants, Pfizer/BioNTech and Moderna's new crown vaccine? References [1] Blumenthal KG, Robinson LB, Camargo CA,, et al.
, (2021).
Acute Allergic Reactions to mRNA COVID-19 Vaccines.
JAMA, DOI: 10.
1001/jama.
2021.
3976 Note: This article aims to introduce medical health Research progress is not a treatment plan recommendation.
If you need guidance on treatment plans, please go to a regular hospital for treatment.
Since many new crown vaccines were approved and put into mass vaccination around the world, there have been more and more data to support the true protective effect of these vaccines.
At the same time, safety is always an important aspect of people's attention.
The Journal of the American Medical Association recently published a study from Massachusetts General Hospital that introduced the incidence of acute allergic reactions after nearly 65,000 medical staff were vaccinated with the mRNA new crown vaccine.
Screenshot source: JAMA This study included 64,900 hospital employees who received the first dose of mRNA COVID-19 vaccine between December 16, 2020 and February 12, 2021, of which 25,929 (40%) received the Pfizer/BioNTech vaccine.
38971 people (60%) received the Moderna vaccine.
The research team followed them until February 18, 2021.
Within 3 days of vaccination, 52,805 people (81%) completed at least one symptom survey.
Investigation methods include emails, text messages, phone calls, mobile apps, etc.
Acute allergic reaction symptoms include itching, rash, hives, swelling and/or respiratory symptoms.
The research team pointed out that since the subjects are medical staff, the reliability of the self-reported data is high.
In order to more accurately identify severe allergic reactions (anaphylaxis), the research team asked allergists or immunologists to review health records, and the final confirmed severe allergic reactions need to meet Brighton standards or NIAID/FAAN (National Institute of Allergy and Infectious Diseases/ At least one of the Food Allergy and Allergic Response Network) standards.
Image source: A total of 1,365 people (2.
10%) from 123RF reported acute allergic reactions.
The proportion of Pfizer/BioNTech vaccinators was 1.
95%, and the proportion of Moderna vaccinators was 2.
20%.
Severe allergic reactions (0.
025%) were confirmed in 16 people, including 7 patients (0.
027%) who received Pfizer/BioNTech new crown vaccine, and 9 patients (0.
023%) who received Moderna new crown vaccine.
People with severe allergic reactions are 41 years old on average, 15 people (94%) are women, 10 people (63%) have a history of allergies, and 5 people (31%) have a history of severe allergies.
The average time for a severe allergic reaction (after vaccination) is 17 minutes (range: 1 minute-120 minutes).
One patient received intensive care, and 9 patients (56%) received intramuscular adrenaline therapy.
All patients with severe allergic reactions recovered without shock or need for intubation.
In addition, 3 patients with severe allergies who had a history of severe allergies did not seek treatment.
Image source: 123RF research team pointed out that in this study of medical staff, nearly 98% of people did not have any symptoms of allergic reactions after vaccinating the mRNA new crown vaccine, and the incidence of severe allergic reactions was 2.
47 cases per 10,000 doses of vaccination.
.
Moreover, most people with severe allergic reactions have a history of allergies.
At the same time, from another perspective, considering that about 5% of adults have a history of severe food allergies and 1% have a history of severe drug allergies, this means that among these medical staff, nearly 4000 have severe food or drug allergies People in history have been vaccinated safely.
In summary, the research team believes that although the incidence of this severe allergic reaction is higher than the rate calculated by the CDC based on passive spontaneous reports (0.
025-0.
11 cases per 10,000 doses of vaccination), it is severely allergic to the mRNA new crown vaccine The overall risk is still very low, roughly equivalent to other common medical exposure risk levels. Related readings on new crown research In June this year, China's vaccination rate is planned to reach 40%.
One article sees that a number of new crown vaccines have been approved across China.
Is the vaccine still useful? Two "The Lancet" shows a strong immune response! Real-world data on AstraZeneca's new crown vaccine was released for the first time.
One shot significantly reduced elderly illnesses and hospitalizations, reducing 92% of new crown infections and 94% of cases.
NEJM published two articles about 600,000 people receiving Pfizer/BioNTech vaccine data in Israel.
NEJM: Targeting multiple How effective are the key variants, Pfizer/BioNTech and Moderna's new crown vaccine? References [1] Blumenthal KG, Robinson LB, Camargo CA,, et al.
, (2021).
Acute Allergic Reactions to mRNA COVID-19 Vaccines.
JAMA, DOI: 10.
1001/jama.
2021.
3976 Note: This article aims to introduce medical health Research progress is not a treatment plan recommendation.
If you need guidance on treatment plans, please go to a regular hospital for treatment.
