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    Home > Chemicals Industry > Chemical Technology > Aristolochic acid A

    Aristolochic acid A

    • Last Update: 2022-06-10
    • Source: Internet
    • Author: User
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    Aristolochic acid A

    Aristolochic acid A

    【Synonyms】Aristolochic acid Ⅰ, Mutong A

    【Structural formula】

    [Molecular formula and molecular weight] C 17 H 11 NO 7 ; 341.
    29

    [Source] North Aristolochia Aristolochia plants Aristolochia contorta Bge.
    Or Aristolochia Aristolochia debi-lis Sieb.
    Et Zucc .
    Dry ripe fruit
    .

    【Properties】Yellow crystal
    .

    This product is soluble in ethanol and methanol
    .

    Melting point: decomposed at 279°C
    .

    【Purity Check】

    TLC

    1.
    Thin layer plate silica gel G

    The upper solution of the developing agent toluene- ethyl acetate -water- formic acid (20:10:1:1)

    Inspection under daylight and ultraviolet light (365nm)

    2.
    Thin layer plate silica gel G

    Developing solvent chloroform - acetone - carboxylic acid (7:3:0.
    1)

    Inspection under daylight and ultraviolet light (365nm)

    High performance liquid chromatography

    Column Diamansil TM C 18 , 5um (4.
    6mm×250mm)

    Mobile phase methanol-0.
    4% phosphoric acid (85:15), 1ml/min

    Detection 260, 310nm

    【Structural identification】388,317,250,223
    .

    1685 (C=O), 1595, 1525, 1469, 1371, 1348, 1271, 1248, 1149, 1041, 947, 810, 754
    .

    EI-MS m/z: 341 [M] + , 325, 295, 280, 278
    .

    1 H-NMR (DMSO) δ: 4.
    05 (3H, s, -OCH 3 ), 6.
    48 (2H, s, -OCH 2 O-), 7.
    36 (1H, d, J=8Hz, H-2), 7.
    81 ( 1H, s, H-7), 7.
    85 (1H, t, H-3), 8.
    58 (1H, s, H-10), 8.
    64 (1H, d, J=8.
    3 Hz, H-4)
    .

    13 C-NMR (DMSO) δ: 146.
    0(C-1), 118.
    4(C-2), 119.
    5(C-3), 131.
    6(C-4), 124.
    1(C-4a), 129.
    9(C-5) , 118.
    8(C-5a), 145.
    6(C-6), 108.
    9(C-7), 156.
    4(C-8), 130.
    3(C-9), 117.
    3(C-9a), 112.
    2(C-10), 116.
    8 (C-10a), 102.
    9 (-OCH 2 O-), 167.
    5 (-COOH), 56.
    2 (-OCH 3 )
    .

    【Storage】Dry and airtightly store
    .

     

     

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