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    Home > Active Ingredient News > Immunology News > Arthritis Rheumatol: Effects of vitamin D and Omega-3 fatty acids on chronic knee pain

    Arthritis Rheumatol: Effects of vitamin D and Omega-3 fatty acids on chronic knee pain

    • Last Update: 2020-07-13
    • Source: Internet
    • Author: User
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    Knee pain caused by osteoarthritis is common in adults

    Previous trials have had inconsistent results in

    vitamin D

    on knee pain treatment, and few have studied marine omega-3 fatty acids (n-3 FA)

    the two-blind, placebo-controlled trial (VITAL) on vitamin D and Omega-3 randomly divided 25,871 U.S

    adults into vitamin D and n-3 FA treatment groups using a two-factor design

    A subgroup of chronic knee pain was identified prior to the random grouping and the arthritis index (WOMAC; 0-100, 100 worst) was assessed annually at the baseline and follow-up during the baseline and follow-up period

    After adjusting age and gender, the repeated measurement model verified the effect of random izedness treatment on WOMAC pain during follow-up

    The WOMAC function and joint stiffness repeat are analyzed

    included 1,398 participants who returned at least one knee pain questionnaire


    The average follow-up time was 5.3 years (SD 0.7)

    There was no difference between the vitamin D or n-3 FA group and the WOMAC pain in the placebo group at any point in the follow-up period

    The interaction time between the two treatments was not statistically significant (vitamin D p-0.41, n-3 FA p-0.77)

    Over time, vitamin D supplementation and n-3 FA supplementation did not significantly affect WOMAC function or stiffness scores

    in a large sample of adult patients with chronic knee pain, the average vitamin D and n-3 fatty acid supplements for 5.3 years did not reduce knee pain or improve function or joint stiffness

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