Arthritis Rheumatol: Effects of vitamin D and Omega-3 fatty acids on chronic knee pain

Knee pain caused by osteoarthritis is common in adultsPrevious trials have had inconsistent results invitamin Don knee pain treatment, and few have studied marine omega-3 fatty acids (n-3 FA)the two-blind, placebo-controlled trial (VITAL) on vitamin D and Omega-3 randomly divided 25,871 U.Sadults into vitamin D and n-3 FA treatment groups using a two-factor designA subgroup of chronic knee pain was identified prior to the random grouping and the arthritis index (WOMAC; 0-100, 100 worst) was assessed annually at the baseline and follow-up during the baseline and follow-up periodAfter adjusting age and gender, the repeated measurement model verified the effect of random izedness treatment on WOMAC pain during follow-upThe WOMAC function and joint stiffness repeat are analyzedincluded 1,398 participants who returned at least one knee pain questionnaireTHE AVERAGE AGE IS 67.7 YEARS, 66% FEMALE, AND THE AVERAGE WOMAC PAIN IS 37 (SD 19)The average follow-up time was 5.3 years (SD 0.7)There was no difference between the vitamin D or n-3 FA group and the WOMAC pain in the placebo group at any point in the follow-up periodThe interaction time between the two treatments was not statistically significant (vitamin D p-0.41, n-3 FA p-0.77)Over time, vitamin D supplementation and n-3 FA supplementation did not significantly affect WOMAC function or stiffness scoresin a large sample of adult patients with chronic knee pain, the average vitamin D and n-3 fatty acid supplements for 5.3 years did not reduce knee pain or improve function or joint stiffness