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    Home > Biochemistry News > Biotechnology News > Arvinas Announces Latest Results of Androgen Receptor PROTAC Therapy

    Arvinas Announces Latest Results of Androgen Receptor PROTAC Therapy

    • Last Update: 2022-03-06
    • Source: Internet
    • Author: User
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    Arvinas announced today that it has published new data showing that bavdegalutamide (also known as ARV-110), a novel PROTAC protein degrader targeting the androgen receptor (AR), targets metastatic castration-resistant prostate cancer (mCRPC), Continue to provide evidence of antitumor activity and patient benefit


    Bavdegalutamide is an AR-targeting PROTAC protein degrader that recruits E3 ubiquitin ligases to the vicinity of ARs, tags ARs with ubiquitin, and guides them for proteasomal degradation


    The latest data shows:

    The PSA50 rate of patients with AR T878X/H875Y mutant tumors was 46% (n=26)


    (Original abridged)

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