As long as we have antibodies in our bodies to fight the new coronavirus?

Antibodies are protein molecules that exhibit a y-shaped structure like a tree stump, which can identify and bind antigens to the tree stump portion.
antibodies to play an antiviral role, the prerequisite is that the antibody to identify and bind to the virus.
and only antibodies that identify proteins on the surface of the virus can have an antiviral effect. On the evening of February 13,
, China Biological, a state-controlled pharmaceutical group, announced that it had completed the collection of plasma for some of the recovered people and carried out the preparation of the new coronavirus special plasma products and the special globulin.
according to Chinese biology, this new coronavirus special blood-free plasma products, donated by rehabilitation patients containing high-efficiency new crown virus-specific antibodies of plasma, after virus inactivation treatment, and against the new coronavirus neutralantibodies, multi-severe primary microorganism scans prepared for the treatment of critical patients with new coronary pneumonia.
see here, some people may think: Is it possible to fight the new coronavirus as long as we have antibodies in our bodies? Huang Bo, deputy director of the Institute of Basic Medicine of the Chinese Academy of Medical Sciences and deputy director of the Department of Immunology at Beijing Concord Medical College, said the facts are not so simple.
not any antibody can antiviral yellow wave introduction, antibody is a protein molecule, they show the same y-shaped structure of the tree, the tree stump part can identify and bind antigens, these antigens are usually heterogeneous proteins.
"There are a variety of heterogeneous proteins in nature, and antibodies are used to identify their tree stump sands, and correspondingly all kinds of them."
," Huang said.
a new type of coronavirus.
the nucleic acid genetic material of the virus is located at the core and is encased in nucleoshell protein.
is a layer of envelopes, which have envelope sin, membrane protein, and nail proteins that are enlarged and shaped like nails.
in addition to the proteins that form the virus structure, the nucleic acid genetic material of the virus can also guide the production of other viral proteins that are not involved in the virus structure.
just that these viral proteins do not exist in viruses, but in infected cells.
"All of these viral proteins are heterogeneous proteins, and for any heterogeneous protein, the body may produce antibodies specific to it."
, people infected with the new coronavirus can produce many different antibodies against the virus.
," Huang said.
, is it possible for every antibody to play an antiviral role? Not necessarily.
" antibodies to play an antiviral role, the prerequisite is that the antibody to identify and bind to the virus.
and only antibodies that identify proteins on the surface of the virus can have an antiviral effect.
," Huang said.
, some viral proteins do not exist in viruses, antibodies against such viral proteins, there is no antiviral effect.
, the virus protein in the virus envelope, antibodies can not be exposed, this part of the antibody also does not have an antiviral effect.
neutral antibodies are the main antiviral force, can play the role of anti-viral antibodies, and how to work? Huang Bo introduced that the new coronavirus makes people sick, through the surface of the virus nail protein and the surface of the lung epithelial cells a protein called ACE2 binding.
then, the shape structure of ACE2 changes and the virus enters the cell.
they use molecules in human cells to synthesize new viruses through chemical reactions.
these new viruses are released outside the cells, they will be re-administered and continue to infect normal cells around them.
but the human body doesn't hold hands.
antibodies produced in the human body against nail proteins can bind to nail proteins on the surface of the virus, blocking their binding to ACE2, thus blocking the virus from entering cells.
", this antibody against nail protein is called neutralantibodies.
neutral antibodies play a protective role by preventing the virus from invading cells, and are the main forces in which antibodies exert antiviral effects.
," Huang said.
neutralizing antibodies against the virus, once produced, can efficiently block the virus from entering the cell.
virus can not enter the cell, can not reproduce, amplification, the virus outside the cell will gradually decompose.
don't forget that in addition to nail protein, the coronavirus surface also has envelope protein and membrane protein.
Huangbo, the latter two proteins may not mediate the virus into the cell, so antibodies bind to them, may not affect the virus into the cell.
, however, non-neutral antibodies that bind to them can mediate the devouring of viral particles by the body's immune cells.
to fully understand the complexity of antibodies in general, the way of antibodies to play a role is divided into two categories: neutral surface antibodies and virus binding, can prevent the virus from entering the cell, the enemy in the "outside the country";
Huangbo added that non-neutral antibodies are mainly mediated viruses into macrophages, playing an antiviral role in the early stages, but may cause immune damage to the lungs in the middle and late stages.
", "In the face of the new crown pneumonia outbreak, antibodies have been placed on too much hope.
but antibodies are not as simple as is generally understood.
we need to have a good understanding of the complexity of antibodies, even the aggravating aspects of the disease.
," Huang said.
Huang bo believes that recognizing this is also important for vaccine development.
because the purpose of vaccination is mainly to allow the body to produce neutralizing antibodies against the viral surface protein.
it's easy to produce antibodies, but it's difficult to produce neutralizing antibodies, which is one of the big challenges in vaccine development.
we should be cautious and carry out in-depth and detailed work. An expert in the field of biological research in
also told Science Daily that there are different strategies for studying drugs for new coronaviruses, such as inhibiting viral binding cells and inhibiting virus-out cells, and must ensure the effectiveness, specificity and safety of the drugs.
Source: Science and Technology Daily Liu yuan garden.