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    Home > Medical News > Medicines Company News > Ascletis announced that the clinical trial application for ASC11, an oral 3CLpro inhibitor, has been accepted by the NMPA

    Ascletis announced that the clinical trial application for ASC11, an oral 3CLpro inhibitor, has been accepted by the NMPA

    • Last Update: 2023-01-01
    • Source: Internet
    • Author: User
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    Ascletis Pharmaceuticals Limited (HKEx: 1672, "Ascletis") today announced that its application for clinical trial (IND) for ASC11, an oral candidate for COVID-19 ("COVID-19") oral candidate (3CLpro), has been accepted
    by the National Medical Products Administration of China ("NMPA").

    In antiviral cell experiments infected with the new coronavirus, ASC11 showed much higher anti-novel coronavirus activity
    than other 3CLpro inhibitors such as nirmatevir, S-217622, PBI-0451 and EDP-235.
    ASC11 maintains potent antiviral activity
    against a variety of widely circulating Omicron variants such as BA.
    1 and BA.
    5.
    In animal models of novel coronavirus infection, ASC11 also exhibits potent antiviral activity
    .

    ASC11 is an oral small molecule candidate independently developed using a variety of proprietary technologies, including molecular simulation docking
    .
    Ascletis has filed patent applications
    worldwide for ASC11 and related compounds and their use in the treatment of viral diseases.

           

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