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    Home > Active Ingredient News > Endocrine System > ASN 2022: Endotrophin as a marker of complications in the type 2 diabetes cohort

    ASN 2022: Endotrophin as a marker of complications in the type 2 diabetes cohort

    • Last Update: 2022-11-14
    • Source: Internet
    • Author: User
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    Hyperglycemia-mediated tissue damage eventually leads to fibrosis
    that affects various organ systems.
    We investigated whether serum and urine endotrophin, a pro-fibrosis signaling molecule, reflecting collagen VI formation, was associated with
    the risk of complications in unselected people with type 2 diabetes.

    Methods Endotrophin
    was measured by PRO-C6 ELISA in serum and urine of 774 patients with type 2 diabetes recruited between 2012 and 2016
    Normalize urine values to urine creatinine levels
    Results were determined by national registries and medical records, including composite renal endpoints (≥40% decline in renal function or renal failure), first major cardiovascular adverse event (MACE), all-cause mortality, progression of proteinuria, heart failure events, and vision-threatening eye disease
    A Cox proportional risk model
    adjusted for general risk factors is applied.

    The cohort included 254 (33%) women with a mean age of ±SD of 65±12 years, a course of diabetes of 17±8.
    8 years, an eGFR of 76 ±24 ml/min/1.
    73 m2, and a median [Q1:Q3] urinary albumin excretion of 12.
    5 [5.
    5] mg/g or g/24 hours
    Depending on the results, the median follow-up was 3.
    0 to 6.
    0 years
    Doubling of serum endothelin was independently associated with composite renal endpoints, first MACE, all-cause mortality, and heart failure events, but not with progression of albuminuria or the development of vision-threatening eye disease (table).

    Doubling of endotrophin in urine was independently associated with the progression of albuminuria and heart failure events, but not with other outcomes (table).

    endotrophin is a risk marker for
    mortality, renal and cardiovascular complications in patients with type 2 diabetes.
    Urotrophin is a risk marker for
    progression in proteinuria and heart failure events.


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