Assessing the invasive and metastatic potential of cancer cells from tissue sections

Rac and Cdc42* are widely studied low molecular weight G proteins that regulate the ability of cancer cells to move, termed their motility and invasiveness

Until now, the motility and invasive ability of cancer cells have only been assessed by a biochemical method called the Rac/Cdc42 pull-down assay

Fortunately, a research team consisting of Prof.

The researchers used a recently developed non-contact stirring technique that uses an alternating electric field to "stir" droplets at extremely high speeds

Their assessment revealed many insights into cellular Rac/Cdc42 activity

According to Associate Professor Masumi Tsuda, "When developing this technique, we initially found it difficult to suppress the staining background and detect specific signals

Article title:

Novel rapid immunohistochemistry using an alternating current electric field identifies Rac and Cdc42 activation in human colon cancer FFPE tissues