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Assessment of Arachidonic Acid Distribution into Phospholipids of Inflammatory Cells

 Last Update: 2020-11-30
 Source: Internet
 Author: User

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Arachidonic acid located at the
sn-2
position of glycerophospholipids is a precursor of an important class of lipid mediators termed eicosanoids (
1
,
2
). The major eicosanoids include leukotrienes, prostaglandins, and thromboxanes. In inflammatory cells, the bulk of AA is esterified into phospholipids (PE, PC, and PI/PS). Arachidonate is further localized in specific subclasses based on different
sn-1
substituents of the glycerol backbone of PC and PE. In mast cells and neutrophils, the major subclasses of PC are 1-acyl- and 1-alkyl-linked, whereas 1-acyl- and 1-alk-1-enyl-linked subclasses constitute the bulk of arachidonate in PE (
3
–
5
). PI is composed mainly of 1-acyl-linked species in these cells.

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