Asymptomatic infections have surged, how effective is the inactivated vaccine, and why is the epidemic uncontrollable?

Guided reading

Guided reading

Yesterday morning, the editor was temporarily notified to go to "nucleic acid" again

Yesterday morning, the editor was temporarily notified to go to "nucleic acid" again

Holding the newly released "nucleic acid has been collected" pass, the editor has mixed feelings in his heart, and without this, he can't go upstairs

Let's take a look at the official news first

The Shanghai Municipal Health Commission announced this morning (21st): From 0 to 24:00 on March 20, 2022, there were 24 new confirmed cases of local new coronary pneumonia and 734 asymptomatic infections

This is not an isolated case.

So, what is an asymptomatic infection? Why are asymptomatic "mushrooms springing up" overnight? In response to the current epidemic, what should we do? Where are the highly popular mRNA vaccines and specific drugs? So, what is an asymptomatic infection? Why are asymptomatic "mushrooms springing up" overnight? In response to the current epidemic, what should we do? Where are the highly popular mRNA vaccines and specific drugs?

01

01 01

Faced with the surge in asymptomatic infections, should we relax our vigilance?

Faced with the surge in asymptomatic infections, should we relax our vigilance? Faced with the surge in asymptomatic infections, should we relax our vigilance?

Asymptomatic infection has two meanings: one is an infected person, and the other is asymptomatic

The first is the new coronavirus infection, that is, the new coronavirus nucleic acid test is positive, which is contagious and requires isolation and treatment

Secondly, asymptomatic, that is to say, there are currently no self-perceived or clinically identifiable symptoms and signs such as fever, dry cough, fatigue, sore throat, decreased sense of smell (taste), diarrhea, and CT imaging has no imaging features of new coronary pneumonia , according to the current situation, it cannot be diagnosed as a "confirmed case"

This round of epidemic situation in China is severe

The domestic epidemic situation is severe The domestic epidemic situation is severe

So, in the face of the surge in the number of asymptomatic infections, can we relax our vigilance?

The answer is clear: no

First of all, the point of an asymptomatic infection is that it is contagious.

According to relevant national requirements, asymptomatic infected persons should also be screened for close contacts and sub-close contacts, screening of high-risk groups, and corresponding site control measures

Secondly, asymptomatic infections will also be diagnosed - there are two confirmed cases: one is cough, fever, fatigue and other symptoms after a period of time; the other is lung CT examination with lesions

Finally, asymptomatic infections are transmitted in the same way as confirmed cases

02

02 02

Why are asymptomatic infections like "mushrooms springing up" recently?

Why are asymptomatic infections like "mushrooms springing up" recently? Why are asymptomatic infections like "mushrooms springing up" recently?

Experts gave us four reasons for analysis:

First, the new coronavirus is constantly mutating

Second, with the vaccination of large-scale populations, the severe rate and mortality rate after infection are continuously decreasing, and the proportion of mild or asymptomatic patients is increasing;

Third, the rapid screening of disease control and the health system, and the rapid nucleic acid response across the country have enabled some early-stage infections to be discovered before they show clinical symptoms;

Fourth, it is related to the immunity of the infected object

Although the toxicity of the new coronavirus is decreasing, we still cannot ignore its high pathogenicity and strong transmissibility

Although the toxicity of the new coronavirus is decreasing, we still cannot ignore its high pathogenicity and strong transmissibility.
Although the toxicity of the new coronavirus is decreasing, we still cannot ignore its high pathogenicity and strong transmissibility.

03

03 03

Is the vaccine useful, why is the epidemic situation uncontrollable?

Is the vaccine useful, why is the epidemic situation uncontrollable? Is the vaccine useful, why is the epidemic situation uncontrollable?

Of course useful
.

At least for now, vaccines are still an important measure in our fight against the new crown epidemic
.

Since the new coronavirus entered our lives in 2019, China has introduced a variety of response plans - nucleic acid, containment and control, vaccination, antigen testing,
etc.

After the new coronavirus has mutated multiple times for two years, compared with the new coronavirus that caused more than 3,800 deaths and made people stunned two years ago, the characteristics of Omicron have now undergone "earth-shaking" changes
.

Recently, an article in the well-known magazine "The Lancet" became popular -

Effectiveness of rAd26-rAd5, ChAdOx1 nCoV-19, and BBIBP-CorV vaccines for risk of infection with SARS-CoV-2 and death due to COVID-19 in people older than 60 years in Argentina: a test-negative, case- control, and retrospective longitudinal study "

Effectiveness of rAd26-rAd5, ChAdOx1 nCoV-19, and BBIBP-CorV vaccines for risk of infection with SARS-CoV-2 and death due to COVID-19 in people older than 60 years in Argentina: a test-negative, case-control , and retrospective longitudinal study Effectiveness of rAd26-rAd5, ChAdOx1 nCoV-19, and BBIBP-CorV vaccines for risk of infection with SARS-CoV-2 and death due to COVID-19 in people older than 60 years in Argentina: a test- negative, case-control, and retrospective longitudinal study

The name is too long, let's go straight to the point: In this paper, Analía Rearte, director of Argentina's National Bureau of Epidemiology and National Strategic Information, gave us an important message by analyzing the effectiveness of vaccines - for people aged 60 and over For the elderly, after receiving two doses of Sinopharm's new crown inactivated vaccine, the effective rate of reducing the risk of death is 85%
.

This is also the first study to evaluate vaccine effectiveness in a real-world setting in a middle-income country
.

Argentine study shows new cases and deaths in the country have dropped significantly

New cases and deaths in the country have dropped significantly , research in Argentina shows a significant reduction in new cases and deaths in the country

More importantly, at the press conference of the Joint Prevention and Control Mechanism of the State Council on March 19, Zheng Zhongwei, director of the Science and Technology Development Center of the National Health and Medical Commission, disclosed the use of Chinese inactivated vaccines in the UAE, and the vaccination rate of the target population in the UAE reached 96%.
%, and booster vaccination accounted for 50%
.

About 70% of them use Chinese vaccines
.
So far this year, there have been only 150 deaths in the UAE, and only nine in the past month
.

It is undeniable that the overall effectiveness of inactivated vaccines is lower than that of mRNA vaccines, but it has a significant effect on preventing severe illness and reducing mortality
.

Recently, many people have questioned the effectiveness of domestically produced inactivated vaccines, but such doubts hope to be based on facts and data
.

Another thing that made Chinese people comment on domestic inactivated vaccines is the Hong Kong epidemic
.
During the recent period of time, the number of newly confirmed cases and deaths in Hong Kong, China continued to increase every day.
As of March 21, the cumulative number of deaths in the fifth wave of the epidemic reached 5,650
.

In fact, this is mainly because the vaccination rate in Hong Kong is too low, and the number of people who have not been vaccinated or only received the first dose accounts for about 88% of the total
.
(mainly the elderly), it is not the effectiveness of inactivated vaccines
.

As of March 18, in the fifth wave of the epidemic in Hong Kong, the number of deaths by age group was compared, and most of the deaths were not vaccinated (Source: Hong Kong SAR Government)

As of March 18, the number of deaths by age group in the fifth wave of the epidemic in Hong Kong was compared, and most of the deaths were not vaccinated (Source: Hong Kong SAR Government) As of March 18, the number of deaths by age group in the fifth wave of the epidemic in Hong Kong In contrast, most of the deaths were not vaccinated (Source: Hong Kong SAR Government)

In the face of the epidemic, we need to take the initiative to attack, and those who have not been vaccinated need to be re-vaccinated
.

04

04

The last piece of the puzzle - special drugs and mRNA vaccines are in the public eye again

The last piece of the puzzle - special drugs and mRNA vaccines are in the public eye again

The epidemic will always pass, and the strict prevention and control measures will one day withdraw from the stage of history, but the revolution has not yet succeeded - we still need to work hard on drugs and vaccines
.

Now the situation of epidemic prevention and control has completely changed, mainly because of the great contagion of Omicron, and we have ushered in the most intense period of conflict between various anti-epidemic strategies
.

Various vaccines, new crown specific drugs, and antigen testing have begun to play a role in the defense lines of various countries.
With the help of these constantly updated technologies, countries such as the United Kingdom and Singapore have begun to slowly loosen control
.

Some time ago, China also quickly launched a self-test kit for COVID-19 antigen detection, and another 21,200 boxes of imported anti-coronavirus drug Paxlovid were sent from Shanghai to the front lines of anti-epidemic in various places as soon as it was approved
.

In addition to drugs, another factor closely related to the mortality rate of the new crown may be more critical - vaccines
.

From the relationship between the mortality rate in Hong Kong and the vaccine booster, as well as the case study of the high vaccination rate and low mortality rate in Singapore, we clearly know the importance of vaccines in this anti-epidemic work
.

Data from Hong Kong show that inactivated vaccines are indeed not as effective as mRNA vaccines, but they are still effective in preventing severe illness.

Data from Hong Kong show that inactivated vaccines are indeed not as effective as mRNA vaccines, but they are still effective in preventing severe illness.
Hong Kong data show that inactivated vaccines are indeed not as effective as mRNA vaccines, but they are still effective in preventing severe illnesses.

At present, the inactivated vaccines in use in China have brought huge benefits to China's epidemic prevention work in the past two years.
However, with the mutation speed of the virus and the phenomenon of vaccine escape of the virus, the voice of mRNA vaccine is getting louder and louder.
Public opinion on whether mRNA vaccines should be introduced has also been brought to the forefront
.

During this year's two sessions, conference spokesman Zhang Yesui told reporters at home and abroad that "some domestic companies are conducting research and development of mRNA new crown vaccines and have made positive progress
.
"

Looking forward to the early launch of the domestic mRNA new crown vaccine
.

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