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With the support of nSFC (project number: 31571378, 31501088), the Kong Zhaosheng Research Group of the National Key Laboratory of Plant Genomics of the Institute of Microbiology of the Chinese Academy of Sciences has made new progress in the construction of cytoskeleton regulation plant cell morphology, and a new mechanism for regulating microtube skeleton dynamic reconstruction and cell formation form through macro-control microtube cutting is explained through genetics, living cell micromicroscopy imaging and mathematical simulation.
research, based on The Augmin Antagonizes At Microtubule Crossovers to Control the Dynamics Of The Plant Cortical Arrays ("Augmin Control Plant Peripheral Microtube Dynamic Tissue at the Intersection of Microtubes" was published April 12 in Current Biology.
Kong Zhaosheng is the author of the newsletter for this article, and Doctoral Student Wang Guangda is the first author.
in the construction of plant cell morphology, the cytoskeleton plays a decisive role by regulating the direction of cell division and cell growth pattern, therefore, the study of the space-time characteristics and dynamic regulation of cytoskeleton is the key to the comprehensive analysis of plant cell morphology.
especially in cell growth, plant cells form a specific peripheral microtube skeleton (Cortical Microtubule Arrays), attached to the inner part of the cytoplasm membrane in a two-dimensional parallel arrangement, providing a track for the synthesis of cellcell microfilament in the cell wall, thus regulating cell growth and morphological construction.
microtubes are highly dynamic and constantly recombine actively, forming a unique microtube array to respond to developmental and external signals. How to assemble microtube skeletons and precisely regulate their dynamic conformation in
plant cells has always been a major scientific problem in the field of plant cell biology. Previous studies
the team have found the mechanism by which The Augmin complex controls the initial assembly of plant cell microtubes (Current Biology, DOI: 10.1016/j.cub.2014.09.053); decoding the Mechanism for the Control of Microtubes in the Katanin complex (E JournalMBO, DOI: 10.15252/embj.201796823; reveals the mechanism by which microtube skeletons and microsilk skeletons coordinate the regulation of leaf epifurging cell morphology (eLife, DOI: 10.7554/eLife.09351).
follow-up studies further found that the augmin complex, in addition to mediating microtubenucleation, had a function that had never been previously reported: negative regulation of microtube cutting mediated by the cutting enzyme katanin.
live cell microimaging found that augmin is more inclined to locate at the microtube intersection, and by inhibiting the cutting of katanin, stable microtube cross-formation, to regulate the dynamic recombination of microtubes and the construction of cell morphology (figure).
further analyzed the mechanism of the active tissue of the regulation of microtubes by the ghmin by genetic and mathematical simulation analysis (motion chart).
the above-mentioned study explains the space-time characteristics and delicate regulation mechanism of the medium microtube skeleton of plant cell morphology at the living cell level and from a four-dimensional space perspective, and reveals a new mechanism of the augmin complex in regulating the dynamic tissue and cell morphology of plant cells.
the results of this study provide an important theoretical basis for the systematic analysis of the cell regulation mechanism of plant cell morphology.
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