ATVB: Effects of age, menopause and obesity on lipid oxide associated with vascular health

Cardiovascular disease is the leading cause of mortality and morbidity in the population, showing significant gender differences, as women suffer from cardiovascular disease later than men.
loss of heart protection in older women may be due to increased post-menotinal arterial stiffness.
free fatty acid metabolites known as lipid oxides, are known to affect vascular function and may be involved in vascular protection of polyunsaturated fatty acids.
recently, Arteriosclerosis, Thrombosis, andVascular Biology, an authoritative journal in the field of cardiovascular medicine, published a study aimed at comparing blood lipid spectrometry in young women (20-55 years of age), older women (over 55 years of age) and older men (over 55 years of age) and determining the association between lipids and cardiovascular risk factors, such as obesity and arterial stiffness.
researchers quantified lipid oxide in plasma samples from a complete clinical trial archive using highly efficient liquid chromatography-series mass spectrometry.
researchers identified three major 12-lipooxygenase products, namely 12-hydroxy-20 carbon tyrenylate, 12-hydroxy-20 carbon-five-acid and 14-hydroxy-22 carbon-hexaene, which are high in the plasma of young women compared to older women and men.
also decreased with obesity and showed a strong negative correlation with arterial stiffness assessed for the pulse rate of the ankle.
based on the multiple linear regression model, these associations persist even when the BMI category is corrected and combined with age, menopause, or estodiol levels.
by linear differentiation analysis, these three lipid oxide combinations can effectively distinguish between participants.
, it can be seen that higher 12-lipooxylipin plasma concentrations and lower arterial stiffness among pre-menoporary women may be important contributors to gender differences in cardiovascular disease.