ATVB: "Heart-Brain Connected"-the accelerated aortic pulse wave speed affects brain gray matter and white matter lesions

Alzheimer's disease is an important public health problem in an aging society
.

In addition to factors such as age and genes, the cause of Alzheimer's disease is still unknown

Heart vascular diseases such as hypertension , is thought to cause Alzheimer's disease risk factors

As the "gold standard" of arterial stiffness measurement, aortic pulse wave velocity (PWV) has been recognized as an independent predictor of cardiovascular disease

Aortic pulse velocity (m/s) is quantified by cardiac magnetic resonance
.

Multimodal 3T brain magnetic resonance imaging includes T1-weighted imaging for quantifying gray matter volume and T2-weighted fluid attenuation inversion recovery imaging for quantifying WMH

diagnosis

278 participants from the Vanderbilt Memory and Aging Project (n=335) (73±7 years old, 58% male, 159 people with normal cognition, 119 people with mild cognitive impairment) were followed on average 4.
9± In 1.
6 years, PWV measurements were taken from September 2012 to November 2014, and longitudinal brain magnetic resonance imaging measurements took place from September 2012 to June 2021
.

Over time, the higher baseline PWV velocity is associated with hippocampus (β=-3.
6[mm3/y]/[m/s]; [95% CI, -7.
2 to -0.
02] P=0.
049) and occipital lobe (β= -34.
2[mm3/y]/[m/s]; [95% CI, -67.
8 to -0.
55] P=0.
046) is related to the reduction of gray matter volume
.

At the same time, the higher PWV speed is related to the increase of temporal lobe gray matter volume over time (β=17.

Over time, the higher baseline PWV velocity is associated with hippocampus (β=-3.

Schematic diagram of the effect of baseline PWV on brain white matter and gray matter

In summary, in the elderly, a higher baseline aortic pulse wave velocity is related to the decrease in gray matter volume and the aggravation of WMHs, and these regional changes are closely related to the occurrence of Alzheimer's disease
.

In summary, in the elderly, a higher baseline aortic pulse wave velocity is related to the decrease in gray matter volume and the aggravation of WMHs, and these regional changes are closely related to the occurrence of Alzheimer's disease
.

In summary, in the elderly, a higher baseline aortic pulse wave velocity is related to the decrease in gray matter volume and the aggravation of WMHs, and these regional changes are closely related to the occurrence of Alzheimer's disease

references:

Elevated Aortic Pulse Wave Velocity Relates to Longitudinal Gray and White Matter Changes.

Elevated Aortic Pulse Wave Velocity Relates to Longitudinal Gray and White Matter Changes.
https://doi.
org/10.
1161/ATVBAHA.
121.
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