ATVB: Lower HDL cholesterol levels were associated with higher exo-white blood cell counts

Animal studies have shown that high-density lipoprotein (HDL) regulates the proliferation and differentiation of hematopoietic stem cells.
recently, Arteriosclerosis, Thrombosis, andVascular Biology, an authoritative journal in the field of cardiovascular medicine, published a study that used a random mondel method to assess whether lower HDL cholesterol was associated with higher white blood cell counts.
researchers included 107,952 participants between the ages of 20 and 100 in the Copenhagen study, including information about HDL cholesterol, white blood cell counts, and nine genetic variants associated with HDL cholesterol.
, HDL cholesterol levels were negatively associated with white blood cell counts in observational analysis of multivariable adjustments.
for continuous variables, HDL cholesterol decreased by 1 mmol/L (39 mg/dL) and white blood cells increased by 5.1% (95% CI 4.7% to 5.4%), neutral granulocytes by 4.5% (95% CI by 4.0% to 4.9%) and lymphocytes by 5.7% (95% CI). 3% to 6.1%), monocytes increased by 5.7% (95% CI by 5.3% to 6.2%), eosinophils increased by 14.8% (95% CI by 13.9% to 15.8%), alkaline granulocytes increased by 3.9% (95% CI by 3.1% to 4.7%).
In genetic analysis using anti-variance weighted analysis for age and gender correction, genetically determined HDL cholesterol decreased by 1mmol/L (39 mg/dL) and white blood cells increased by 2.2% (95% CI by 0.3% to 4.1%), and lymphocytes increased by 4.3%. (95% CI was 1.6% - 7.1%), monocytes increased by 4.3% (95% CI by 2.6% to 6.1%) and eosinophils increased by 4.8% (95% CI by 1.2% to 8.5%).
result, lower HDL cholesterol levels were associated with higher exolete counts, including lymphocytes, monocytes, and eosinophils.
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