ATVB: The causal relationship between blood lipids and COVID-19 risk

Coronavirus disease 2019 ( COVID-19 ) is caused by the severe acute respiratory syndrome coronavirus 2 infection and caused a global pandemic
.

Recently, the heart blood vessels published on the prestigious journal areas of Arteriosclerosis, Thrombosis, and Vascular Biology research article, the researchers conducted two sample Mendelian randomization (MR) analysis to investigate lipids and COVID 19-susceptibility and severity of Causal effect between
.

The researchers used the results data from the British Biobank (1221 cases and 4117 controls) and observed that after Bonferroni correction, dyslipidemia (odds ratio [OR] is 1.
27 [95% CI is 1.
08-1.
49], P =3.
18×10-3), total cholesterol (OR is 1.
19[95%CI is 1.
07-1.
32], P=8.
54×10−4) and ApoB (apolipoprotein B; OR is 1.
18[95%CI is 1.
07- 1.
29], P=1.
01×10−3) and potential positive causal effects between COVID-19 susceptibility
.

In addition, the researchers used the result data of the Host Genetics Initiative (14,134 cases and 1,284,876 controls) to determine total cholesterol (OR 1.
01 [95% CI 1.
00-1.
02], P=2.
29×10−2) and ApoB (OR is 1.
01[95%CI is 1.
00-1.
02], P=2.
22×10-2) and the effect of COVID-19 susceptibility
.

Kun Zhang.