Autopsy results of the world's largest new crown pneumonia patient to date

New crown pneumonia is still rampant around the world, with more than 7 million confirmed cases of new coronapneumonia and more than 400,000 deaths so far, according to real-time data from Johns Hopkins University in the United StatesOn one side, as patient and death shrank, scientists, research institutions and pharmaceutical companies around the world are working together in a time race against new coronapneumonia, from pathology research to vaccine drug developmentAmong them, the autopsy of the remains is regarded as one of the indispensable researches to obtain the pathology of new coronary pneumonia, which is of great help to explore the clinical pathological changes and disease mechanisms of patients with new coronary pneumonia, and can fundamentally find the pathogenicity and lethality of the new coronary pneumonia, which provides an important basis for the clinical treatment of patientsin late February, Liu Liang, president of the Hubei Provincial Association for Forensic Identification and a professor of forensic pathology at Tongji Medical College of Huazhong University of Science and Technology, published the first autopsy report on the first case of new crown pneumonia in the Journal of Forensic MedicineRecently, in the National Science Review, Yu Xiuwu and others published a research paper entitled "Octy of COVID-19 victims in China", a total of 91 cases of new crown pneumonia patients autopsy results summarized, of which 37 cases for systematic autopsies, 54 cases for minimally invasive autopsies, from the number of the world's largest new coronavirus pneumonia autopsy report, the researchers said that SARS-CoV-2 infection can cause damage to multiple organs and tissues in the body, accompanied by obvious and widespread lung lesions, although SARS-CoV-2 infection caused by the pathological characteristics of lung lesions similar to SARS infection, but there are some differencespreviously, when Liu Liang's team carried out the first case of new coronary pneumonia puncture, it was also found that the new coronavirus and SARS and MERS coronavirus caused by the pathological characteristics are very similar, but from the general observation of that case of the autopsy, lung fibrosis and reality did not cause SARS-induced lesions serious, and the osmotic reaction is more obvious than SARSOne possible reason given at the time was that the patient had a shorter course of life only 15 days from diagnosis to deathin this autopsy, the researchers in some patients found a strong space-time heterogeneous lesions, of which respiratory system lesions are the most significant, the patient's trachea and bronchial mucosa congestion, secretion increased, local epithelial shedding, the actual changes in the lung showed a difference in the range distributionunder the optical microscope, the patient's physical area has diffuse alveoli damage and oozing inflammation, fibrosis in the alveolar cavity and transparent membrane formation, oozing cells are mainly mononucleic and white blood cell macrophages, type II alveolar epithelial cells significantly increased, bureau-based alveoblasts peeling significantlyPart of the bronchial mucosal epithelial shedding, mucus protein accumulation, mucous blockage formation, a small number of alveoli over-inflated, alveostic interval rupture or cystic cavity formation, pulmonary tissue lesions bleeding, necrosis, hemorrhagic infarction, electroscopic subsydgeal epithelial and type II alcosatropic epithelial cell cytoplasm visible coronavirus particles, in a longer course of cases, also appeared pulmonary alcotosis and pulmonary fibrosisimmunohistic staining results showed that THE SARS-CoV-2 virus entered the receptor (i.eACE2) positive in some trachea and bronchial mucosal epithelial cells, and the trachea and lung tissue were positive for SARS-CoV-2 nucleic acid, which is considered the pathological basis for fatal respiratory failure in patients, the researchers also found that SARS-CoV-2 infection causes acute damage to multiple organs in the bodySignificant lesions in lymphatic hematopoietic organs; reduced CD4 plus T and CD8-T cells in the lymph nodes, hyperplorcy spleen hyperplorcys in the spleen; myocardial muscle seludes, exudative necrosis; interstitial edema, mild immersion of mononucleosis; and gallbladder height Fully charged, mucous epithelial shedding, liver cell degeneration, spot necrosis, fragmentation, bridging or a large number of necrosis osmosis, etc.; kidney performance as renal small blood, sectional hyperpluse or necrosis, nephrative glomerular cavity of the kidney glomerular cavityThe esophagus, stomach and intestinal mucosa showed varying degrees of degeneration, necrosis and sheddingPatients' testicles show varying degrees of sperm cell reduction and damageThe patient's brain observed changes in cerebral congestion, edema, and part of neuronal parallel lines and ischemic, as well as some cases of neurosopharyngeal pain, with a few cases of cerebral palsy, the researchers noted in the article that in the autopsies of some elderly patients, they found a large number of underlying diseases, including respiratory diseases (chronic bronchitis, bronchodilation, etc.), cardiovascular disease (atherosclerosis, hypertrophy, etc.), digestive diseases (viral hepatitis and cirrhosis, chronic gastritis, stone gallbladder, etc.), urological diseases (renal cysts, chronic gallbladders, etc.) Cystitis, prostate hyperplasia, etc.), brain damage (geriatric cerebral infarction), these diseases and SARS-CoV-2 infection caused by acute injury caused by the pathological basis of multi-organ dysfunction syndrome, lung, heart, kidney and liver lesions will have more serious consequences, and autopsy cases also found that the main cause of death is organ dysfunction syndrome, especially acute respiratory distress syndrome.