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4.
Case 1
This case is about the synthesis of 3-bromo-5-chloromethyl-1,2,4-oxadiazole through a two-step reaction of bromination and cyclization
The person involved noticed small blisters on his hands after the third week of the synthesis project, but did not care
Figure 19-3 Initial hospitalization
Figure 19-4 After two months of treatment, the arms, soles and back are all scarred
Case study: From the perspective of the contact process and the time of onset, bromine, intermediates, chloroacetonitrile and products may all be allergens
Lesson lesson: The compound in this case has a very strong sensitization effect.
Case 2
A certain research team synthesized the following compounds, and almost all people in contact with them have allergic symptoms one after another, as shown in Figure 19-5
Figure 19-5 Symptoms of hand allergy
Symptoms vary, some have erythema, some have blisters