Awareness and control of allergenic chemicals (6)

(2) Functional groups of sensitizing chemicals

Almost all chemically reactive functional groups have been found in allergenic chemicals

1.

2.

There are many kinds of chemicals that can cause allergies

The chemical nature of antigen-antibody binding is extremely complicated, except that the functional groups of the compound are affected by the binding of the pure protein in the body through factors such as electricity and gravity; more importantly, the arrangement and combination of these related groups and the three-dimensional structure of the skeleton are suitable The space of the pure protein to be embedded, like the drug-receptor binding mechanism and the quantitative structure-activity relationship, needs to be studied specifically

So far, the chemical nature of antigen-antibody binding has not been fully elucidated, so it is not yet possible to accurately predict whether a chemical substance can bind to the pure protein in the body to form a potential complete antigen and whether it constitutes sensitization to the human body based on its chemical structure

In addition, there are differences between individuals.

For example, a combination of items into pyrimidine derivatives substituted with halogens at positions 2, 4, and 5:

Of the 11 people in the project team, 2 people have never had allergic reactions, while the other 9 people have allergic reactions of varying degrees.

In short, to prevent and reduce allergic injuries caused by allergenic chemicals, it is very important to develop good chemical experiment operation habits, from picking and sampling, feeding, and reaction, to post-processing, utensil cleaning, waste disposal, etc.

Related Links: Awareness and Control of Allergenic Chemicals (5)